Analgesics Class 4 Flashcards

1
Q

Opioid prototype drug

A

morphine

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2
Q

morphine
Opioid Analgesic
Action

A

Activates mu and kappa receptors

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3
Q

morphine
Opioid Analgesic
Primary Use

A

Analgesia

Anesthesia

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4
Q

morphine
Opioid Analgesic
Adverse effects

A

Respiratory depression
Sedation
Constipation
N/V

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5
Q

Opioid Antagonist

prototype drug

A

Narcan

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6
Q

Opioid Antagonist

Action

A

Blocks mu and kappa receptors

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7
Q

Opioid Antagonist

Primary Use

A

Reverse respiratory depression

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8
Q

Treatment for Opioid Dependence

A

Methadone maintenance

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9
Q

Nonopioid Analgesic

Prototype drug

A

Acetaminophen Tylenol

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10
Q

Nonopioid Analgesic
Acetaminophen
Action

A

Treats mild pain by mildly inhibiting prostaglandins

Reduces fever by vasodilation

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11
Q

Nonopioid Analgesic
Acetaminophen
Primary Use

A

Antipyretic

Analgesic

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12
Q

Nonopioid Analgesic
Acetaminophen
Adverse Effects

A

Overdoses are lethal

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13
Q

NSAID
ibuprofen
Action

A

Inhibits COX receptors and prevents formation of prostaglandins

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14
Q

NSAID
ibuprofen
Primary Use

A

Analgesic

Anti-inflammatory

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15
Q

NSAID
ibuprofen
Adverse effects

A

GI upset

Acute renal failure

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16
Q

Salicylates
Aspirin
Primary use

A

Anticoagulant
Antipyretic
Anti-inflammatory
Analgesic

17
Q

Salicylates
Aspirin
Adverse effects

A

Bleeding
GI distress
Increase action of oral hypoglycemics

18
Q

Selective COX-2 Inhibitors
celecoxib Celebrex
Action

A

Inhibits COX-2 to prevent formation of prostaglandins

19
Q

Selective COX-2 Inhibitors
celecoxib Celebrex
Primary Use

A

Analgesic
Antipyretic
Anti-inflammatory

20
Q

Selective COX-2 Inhibitors
celecoxib Celebrex
Adverse effects

A

Mild and related to GI

21
Q

Antimigraine
sumatriptan (Imitrex)
Action

A

Serotonin agonists

Constrict intracranial vessels

22
Q

Antimigraine
sumatriptan (Imitrex)
Primary use

A

Abort migraines

23
Q

Antimigraine
sumatriptan (Imitrex)
Adverse effects

A

GI upset

Increase BP

24
Q

Antimigraine
ergotamine tartrate (Ergostat)
Action

A

Promote vasoconstriction

25
Q

Antimigraine
ergotamine tartrate (Ergostat)
Primary use

A

Terminate ongoing migraines

26
Q

Antimigraine
ergotamine tartrate (Ergostat)
Adverse effects

A

S/S of vasoconstriction or decrease in blood flow

ie. numbness, tingling, angina-like pain, tachycardia

27
Q

What 4 drugs treat prophylaxis of migraines?

A

Beta blockers
Calcium channel blockers
Antidepressants
Antiseizures

28
Q

Stimulation of Histamine 1 receptors

A
Itching
Pain
Edema
Vasodilation
Bronchoconstriction
29
Q

Stimulation of Histamine 2 receptors

A

Secretion of hydrochloric acid in the stomach

30
Q

Inhibition of COX-1

A

Bleeding
Gastric upset
Reduced renal function

31
Q

Inhibition of COX-2

A

Suppresses inflammation

32
Q

Systemic glucocorticoids
prednisone Meticorten
Action

A

Suppresses histamine and prostaglandins

33
Q

Systemic glucocorticoids
prednisone Meticorten
Primary use

A

Treat inflammation

34
Q

Systemic glucocorticoids
prednisone Meticorten
Adverse effects

A

Long term: Cushing’s syndrome, adrenal gland atrophy, cataracts, corticosteroids, peptic ulcers
Short term: insomnia, increased energy, GI upset, increased appetite

35
Q

Salicylates
Aspirin
Contraindication

A

Pediatrics

Reye’s Syndrome: confusion, lethargy, altered LOC, N/V