Anaesthetics - Local Flashcards
Which of the following is the core local anaesthetic that we need to be aware of?
1 - Propofol
2 - Halogenated ether
3 - Levodopa
4 - Lidocaine
4 - Lidocaine
What is the mechanism of action of lidocaine?
1 - bind to extracellular Na+ and block entry into the cell
2 - diffuse into cells and block Na+ channels intercellularly
3 inhibit extracellular K+ channels, keeping them open and K+ leaves
4 - blocks Ca2+ channels
2 - diffuse into cells and block Na+ channels intercellularly
Which of the following is an indication to use lidocaine in adults?
1 - neuropathic pain in adults
2 - chronic joint pain
3 - prophylactic for migraines
4 - alcohol withdrawal
1 - neuropathic pain in adults
Which of the following is NOT an adverse event of lidocaine when administered via IV?
1 - Acute pancreatitis
2 - Dizziness
3 - Cardiac arrest
4 - Hypotension
5 - Tremor
6 - Vomiting
1 - Acute pancreatitis
Which of the following is the 1st line medication for migraines?
1 - gabapentin
2 - triptan
3 - duloxetine
4 - morphine
2 - triptan
Triptan is the 1st line medication for migraines. What is the mechanism of action of this drug?
1 - selectively binds to serotonin receptors and inhibits them, inducing vasoconstriction
2 - dopamine agonist
3 - selectively binds to serotonin receptors acting as an agonist, inducing vasodilation
4 - inhibits Ca2+ channels and inhibiting serotonin release
1 - selectively binds to serotonin receptors and inhibits them, inducing vasoconstriction
- vasodilation of cranial blood vessels is what is associated with migraines
- has also been shown to inhibit trigeminal nerve pain
- constricts carotid arterial circulation, but does not limit cerebral blood flow
Triptan is the 1st line medication for migraines. Which of the following is NOT an adverse event of triptan?
1 - AKI
2 - Dizziness
3 - Hypertension
4 - Myalgia
5 - Vomiting
1 - AKI
- also interacts with SSRIs causing serotonin syndrome
