Anaesthetics Drugs

Question 1

Give 2 examples of inhalation general anaesthetic

Answer 1

Nitrous oxide and Isoflurane (Sevoflurane is used in day care surgery, isoflurane is not used for induction due to its pungent odour)

Question 2

Give 2 examples of IV general anaesthetic

Answer 2

Thiopental sodium and propofol

Question 3

Which GABA receptor do most general anaesthetic act on? Is the GABA receptor inhibited or potentiated?
Name the 4 general anaesthetics that will not bind as easily to this receptor

Answer 3

GABAa

All GA binds readily to GABAa receptors except for Ketamine, Xenon, Cyclopropane and Nitrous Oxide

Question 4

Which glutamate receptor is most acted on by GA?

Answer 4

NMDA receptors

Question 5

What does higher lipid solubility of the GA mean?

Answer 5

Higher lipid solubility means that the GA is more potent and there is less need for frequent administration.

Question 6

Give 2 examples of volatile general anaesthetics. How are they removed from the body?

Answer 6

Inhaled general anaesthetics: Nitrous oxide and Sevoflurane.

Removed from the body by ventilation. (breathing it out)

Question 7

How do patients recover from IV general anaesthetics and how are IV general anaesthetics removed from the body?

Answer 7

IV general anaesthetics are non-volatile. Recovery is by redistribution of the drug in the body. Removal is by metabolism and excretion.