Anabolic Reaction Pt.2 Flashcards

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1
Q

What is Adenosine
diphosphoglucose (ADPG)?

A

A precursor for glycogen
biosynthesis

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2
Q

What is Uridine diphosphoglucose
(UDPG)?

A

Precursor of some glucose
derivatives needed for biosynthesis of important polysaccharides that makes important bacteria
Examples: N- acetylglucosamine, N-acetylmuramic acid

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3
Q

Where does the carbon skeleton come from?

A

Kreb cycle or glycolysis

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4
Q

Describe the details of Biosyntyhesis of Fatty Acids

A

Fatty acids made 2 carbon atoms at a time and Requires Acyl carrier protein (ACP) that connects sugars together and NADPH converted to NADP to remove oxygen

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5
Q

What is Nucleotide anabolism and the 2 types of biosynthesis of it?

A

Synthesis of pentose sugar;
Pyrimidine Biosynthesis has an Orotic acid precursor and activated ribose is added with a UMP intermediate -> CTP and TMP
Purine Biosynthesis Starts from amino acids, CO2 and formyl groups, Formyl groups added with the help of folic acid Inosinic acid (IMP) intermediate -> AMP and GMP

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6
Q

Describe the Inhibitors of Nucleotide Synthesis

A

Methotrexate, aminopterin inhibits tetrahydrofolate to TMP
6 –mercaptopurine Inhibits conversion of IMP to AMP
5 fluoropyrimidine Blocks conversion on UMP to TMP
Sulfonamides block folic acid synthesis

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