Amnesia Flashcards

1
Q

What is amnesia?

A

Loss of memory and/or learning due to some kind damage to the brain

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2
Q

What is anterograde amnesia?

A

Inability to form new (long-term or short-term memories)

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3
Q

What is retrograde amnesia?

A

Inability to retrieve memories from the past

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4
Q

What did HM have removed?

What was he unable to do?

What did this help to identify?

A

Bilateral Medial Temporal Lobes

Acquire new declarative memories

Medial temporal lobes as a key region in declarative memory

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5
Q

What is located in temporal lobes?

A

The hippocampus

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6
Q

What did HM have preserved?

What could he not do?

What is global amnesia?

A

Memory of the past and good working memory

Form new LTM

Affects all sensory modalities

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7
Q

Anterograde amnesia

What were there problems with?

A

Declarative memory

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8
Q

What is explicit (declarative) memory?

A

Requires conscious recall e.g. What did I eat for dinner last night

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9
Q

What is implicit (procedural) memory?

A

Doesn’t require conscious recall e.g. Walking, riding a bike

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10
Q

What amnesia did KC have?

Targeting what?

A

Anterograde

Only episodic memory spared semantic memory

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11
Q

What is episodic memory?

A

Recall of personal info

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12
Q

What is semantic memory?

A

Recall of facts

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13
Q

What does the inability to retrieve episodic memories lead to?

Are the same brain areas involved?

A

Problems imaging the future

Yes

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14
Q

What was the initial concept of RA?

How are memories lost? What are older memories? What are younger memories?

What is Ribot’s law?

A

It was graded

Backwards
Stronger
Weaker (temporally graded)

Arguments in favour of the notion of consolidation

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15
Q

What does graded or ungraded retrograde amnesia depend on?

What is area of the brain is graded?

What areas of the brain are ungraded?

A

Anatomical location of brain damage

Medial temporal lobe

Lateral and anterior temporal lobe

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16
Q

What is Korsakoff’s syndrome?

What does it cause?

What is it a loss of?

What can it improve with?

Is there an area of specific damage?

A

Thiamine (vitamin B1) deficiency due to alcohol abuse

Both AA and RA

Temporal sequence and confusion

Thiamine transfusions

No

17
Q

What is hypoxia?

What does it lead to?

What is common?

What can children with hypnosis still do? Applying what?

A

Consequence of reduced oxygen supply to the brain

Hippocampal damage

AA for episodic info

Perform in school
Semantic info

18
Q

What is transient global amnesia?

What may it follow? When is it more common?

What is more common?

What is it the temporary dysfunction of?

A

Temporary (4-12 hours) confusion and loss of memory

A traumatic event
It is more common in old age

AA but RA (episodic) more variable during acute phase

Limbic-hippocampal network

19
Q

What is Alzheimer’s disease?

Leading to what?

A

Plaques and neurofibrillary tangles

Medial-temporal lobe (hippocampus) atrophy

20
Q

What is Chronic Traumatic Encephalopathy?

A

Repetitive head traumas and neurofibrillary tangles