Amiodarone Hydrocholoride

Question 1

Amiodarone Hydrochloride - Indications (5)

Answer 1

Stable wide complex tachycardia; V-fib; Pulseless; V-tach; *May be ordered in Junctional and Multifocal Atrial Tachycardia

Question 2

Amiodarone Hydrochloride - Contraindications (5)

Answer 2

Breast-feeding patients in cardiogenic shock, AV blocks, symptomatic bradycardia, sinus bradycardia with sinus node dysfunction, hypersensitivity

Question 3

Amiodarone Hydrochloride - MoA

Answer 3

Decreases sinus automaticity, reduces the speed of conduction (-dromotropy), increases the refractory period of the AV node, prolongs the action potential duration in all cardiac tissue

Question 4

Amiodarone Hydrochloride - Pharmacokinetics

Answer 4

Onset- 1-30min, Duration- 1-3hrs

Question 5

Amiodarone Hydrochloride - Reactions

Answer 5

Hypotension, bradycardia, prolonged PR interval, pulmonary toxicity. May react with warfarin (Coumadin®), quinidine, digoxin, procainamide and phenytoin

Question 6

Amiodarone Hydrochloride - Dosage

Answer 6

Adult: 150 mg SLOW IVP over 10 mins for JT, MAT, Stable wide complex tachycardia, may repeat once. 300 mg rapid IVP for pulseless VF or VT
Peds: Safety and efficacy not established

Question 7

Amiodarone Hydrochloride - Classification

Answer 7

Class III anti-dysrhythmic (potassium channel blocker)

Question 8

Amiodarone Hydrochloride - Pregnancy Category

Answer 8

D