Adenosine

Question 1

Adenosine - Classification

Answer 1

Endogenous nucleotide

Question 2

Adenosine - Indications (2)

Answer 2

Narrow or wide complex tachycardia with heart rate >150bpm

Question 3

Adenosine - Pregnancy Category

Answer 3

C

Question 4

Adenosine - Contraindications (7)

Answer 4

Second or third degree AV blocks, SSS, atrial flutter, atrial fibrillation, ventricular tachycardia, hypersensitivity to adenosine

Question 5

Adenosine - MoA

Answer 5

Directly acts on sinus pacemaker cells and vagal nerve terminals to decrease chronotropic and dromotropic activity without causing negative inotropic effects.

Question 6

Adenosine - Pharmacokinetics

Answer 6

Onset- 5-20sec, Peak- 20-30sec,

Question 7

Adenosine - Reactions (11)

Answer 7

Facial flushing, paresthesia, headache, diaphoresis, hypotension, chest pain, palpitations, SOB, nausea, lightheadedness, transient asystole (average 6 sec)

Question 8

Adenosine - Dosage

Answer 8

Adult: 6 mg rapid IVP. If no effect after 1-2 mins, 12 mg rapid IVP. (*12 mg may be repeated in unaffected for a max dose of 30 mg)
Peds: 0.1 - 0.2 mg/kg rapid IVP; max single dose of 12 mg