Aminoglycosides Flashcards
What are Aminoglycosides?
Big gun antibiotics.
Treat serious, life threatening, resistant infections
All aminoglycosides end in?
“mycin” Vancomycin
For Aminoglycosides, think:
A Mean Old Mycin
If it has “thro” in it you?
Throw it out…Zithromycin.
It treats a minor infection
Toxic effects of aminoglycosides?
Ototoxicity
Nephrotoxicity
Cranial nerve 8 (vestibulocochlear nerve) which senses sound.
The one Aminoglycoside that doesn’t end in Mycin?
Amikacin
What is another word for aminoglycoside?
Glycopeptide
In aminoglycoside use monitor?
Hearing, balance, tinnitus & creatinine (best indicator of renal function)
If you have to pick which side effect/assessment you do first, pick
Ototoxicity (Ears)
Frequency of administration for aminoglycosides?
Q8H
Aminoglycoside route of administration?
Im or IV
Aminoglycosides are given PO for what 3 reasons?
Hepatic Encephalopathy
Pre-op bowel surgery.
C diff
What is Hepatic Encephalopathy also called?
Liver Coma,
Ammonia-Induced Encephalopathy
If fluid resuscitation is used in shock, there will be
Increased Urine Output
Neomycin and Kanmycin are used for what?
Bowel sterilzation?
Can also be given for C.Diff
Who can sterilize my bowel?
“Neo” “Kan”
If you give aminoglycosides PO, do you have to worry about side effects?
No
Hepatic Encephalopathy is caused by?
High ammonia levels
What raises ammonia levels the most?
Ecoli in the gut
Why do you draw TAP levels?
Narrow therapeutic Window
When do you draw a trough level?
30 minutes before the next scheduled dose.
When do you draw a sublingual peak level?
5-10 minutes after it is dissolved.
When do you draw a IV peak level?
15-30 minutes after dose is finished.
When do you draw a IM peak level?
30-60 minutes after given
If you must pick a time to draw the peak, pick the highest amount of time without going over the limits
So for IV, Pick 30 Minutes, not 15.
