Aminoglycosides

Question 1

A mean old mycin

Answer 1

Aminoglycosides

Question 2

• used to treat serious, resistant, life-threatening, Gram negatives infections
  o Examples are: TB, septic peritonitis, fulminating pyelonephritis, septic shock, infection from third degree wound covering >80% of the body
  o However, sinusitis, otitis media, bladder infection, viral pharyngitis, and strep throat are not old mean infections and are not treated with a mean old mycin

Answer 2

AMINOGLYCOSIDES

Question 3

How to tell by the name when a drug is an aminoglycoside

Answer 3

• Gentamycin, Vancomycin, and Clindamycin, Streptomycin, Cleomycin, Tobramycin
• Not all drugs ending in mycin are aminoglycosides
o Azithromycin, Clarithromycin, Erythromycin … All have THRO in the middle … So, THRO them off the “Mean Old Mycin” list

Question 4

What are the toxic effects of aminoglycosides?

Answer 4

1. Ear: balance, tinnititus (ringing of the ear)
2. Kidney: monitor creatinine

Question 5

What is the #1 action/(purpose)” of an oral mycin

What are examples

Answer 5

To sterilize bowel
(examples: Neomycin and Kanamycin)

Question 6

When are the 2 cases where Mean Old Mycin are given PO?

Answer 6

1. Hepatic encephalopathy (or hepatic coma) where ammonia level gets too high —- to kill. E. Coli (E. coli in the gut is the #1 producer of ammonia, which at toxic levels, lead to encephalopathy)
2. Pre-op bowel surgery: to sterilize the bowel before surgery

In both cases, the ABX stays in the gut (not absorbed), sterilizes the bowel, and would not be toxic

Question 7

____________ is when drugs is at their lowest concentration in the
pt’s blood

Answer 7

Troughs