Alzheimer treatments Flashcards
1
Q
Treatments for mild-moderate Alzheimer disease
A
Galantamine, Tacrine, Donepezil and Rivastigmine
2
Q
Treatments for Moderate to severe alzheimer disease
A
Memantine
3
Q
Possible treatment for alzheimer
A
Ginko Biloba
4
Q
Mechanism of mild to moderate treatments
A
Inhibit AChE -> causes increase excitation
5
Q
Mechanism of memantine
A
NMDA receptor antagonist
6
Q
Adverse effects of memantine
A
Dizzy, headache, confusion, constipation
7
Q
ADME of galantamine
A
Caution when taking w/Antidepressants – may interfere w/Galantamine clearance
8
Q
Disadvantages of Rivastigmine and Tacrine
A
Short half life.
Rivastigmine = 2x a day
Tacrine = Many times a day
9
Q
Side effects of mild-moderate treatments
A
Stomach ulcer risk and tacrine can cause liver damage
