Alzheimer's Disease

Question 0

Amyloid Precursor Protein (APP)

Answer 0

Is cut by a or b- secretase to form AB40 or AB 42

Question 1

Alzheimer’s starts in the…

Answer 1

Hippocampus

–> Lang, logic, emotion, long-term memory

Question 2

Secretase (alpha, beta)

Answer 2

Amyloid precursor protein (APP) –>
A. AB40
B. AB42

Question 3

Normal Ab42

Answer 3

Moderates brain activity to prevent neurons from firing at high, damaging levels(suppresses over activity, anti seizure)

Question 4

Too much h Ab42… And forms…

Answer 4

…decreases neuron firing so much as to cause apoptosis.

…form plaques

Question 5

Non-Steroidal anti-inflammatory drugs (NSAIDs)

Answer 5

Ibuprofen, Advil, Morton, Nuprin
Decrease Ab42.
Aspirin, steroidal anti-inflammatory drugs don’t work to prevent AD

Question 6

Ppl with ____ don’t get AD

Answer 6

Rheumatoid arthritis

Question 7

Ab42 needs ___ to kill cell

Answer 7

Tau tangles

Question 8

Normal tau …

Answer 8

Stabilizes micro tubules of cytoskeleton.

Question 9

Damaged tau…

Answer 9

Disassociates from micro tubules, destroying the cytoskeleton. Then aggregates into tangles.

Question 10

DNA damage ___ in AD patients

Answer 10

Increases

Question 11

_____–>BDNF

Answer 11

bCl-2

Question 12

Brain Derived Neurotrophic Factor (BDNF)

Answer 12

Prevents apoptosis. Protects neurons from dying.

Question 13

Default network

Answer 13

Activated when not engaged in high level cognition.

Increases Beta amyloid 42.

Question 14

…. Causes less default system –> more BDNF–> less AB42

Answer 14

INCREASE: learning, exercise, sleep
DECREASE: fat and sugar diet, stress