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Pathophysiology > Alterations In HEmostasis > Flashcards

Alterations In HEmostasis Flashcards

1
Q

He most asks

A

Stopping of abnormal blood flow
Normal: Seals broken blood vessels
Abnormal: Inappropriate clotting and Insufficient clotting

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2
Q

Thrombopoietin

A

Stimulate production

Made in the liver, kidney, smooth muscle, bone marrow

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3
Q

Megakaryocytes

A

Formed in bone marrow

Break apart to form may platelets

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4
Q

Platelets

A

Live 8-9 days in circulation
Many are sorted in spleen
Released when needed

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5
Q

Coagulation factors

A

Needed to complete coagulation cascade.

Plasma proteins and Calcium

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6
Q

Plasma proteins

A

Most are synthesized by the liver
Von willebran factor made by endothelium
Rom numeral factors (8,9)
Produce the coagulation cascade

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7
Q

Calcium (factor IV)

A

Essential in all but 2 steps

Hypercalcimia: clotting

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8
Q

Vessel spasm

A

Injury which cause the vessel spasm to control the flow of blood

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9
Q

Platelet plug

A

Stop blood loss and blood flow

Von Willebran factor, Thromboxane and ADP

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10
Q

Coagulation

A

Thrombin causes Fibrinogen to become fibrin. Fibrin then makes the clot

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11
Q

Clot Retraction

A

Healing has taken place the clot then retracts

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12
Q

Clot lysis

A

Plasminogen activators cause plasminogen to become plasminogen.. Plasmin then breaks down the clot and gets rid of it

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13
Q

Intrinsic system

A

Vessel injury

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14
Q

Extrinsic System

A

Tissue injury

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15
Q

Hypercoagulability: Increase in platelet function

A 
Atherosclerosis 
DM 
Smoking
Hyperlipidemia
Increased Platelet count
Genetics
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16
Q

Hypercoagulability: Increase Clotting activity

A 
Pregnancy
Oral contraceptives 
Immobility
Post op
CHF 
Malignancy
17
Q

Platelet disorders

A

Thromobocytosis

Thrombocytopenia

18
Q

Thromobocytosis

A

7500,000 + platelets

19
Q

Thrombocytopenia

A

100,000 or less platelets

20
Q

ITP

A

Auto immune destruction of platelets (antibodies) type two hyper sensitivity
Kids recover, adults chronic
Bruising/Bleeding
Steroids/immune suppressants

21
Q

TTP

A

Widespread platelet thrombi in arterioles caused by enzyme deficiency.
Rare- very severe
Petechiae and purport
Plasmapheresis and FFP infusion fives 80% recovery: takes blood out and cleans it and puts it back in

22
Q

Genetic Bleeding Disorders

A

Von Willebrand (most common and mild)
Hemophilia A
DDAVP
Hemophilia B

Pathophysiology (5 decks)

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