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IMMUNO > Alphabet Soup > Flashcards

Alphabet Soup Flashcards

1
Q

IL-1 (+IL-1B)

A

Pro-inflammatory cytokine produced by sentinel cells, upregulate expression of selectins, IL-1B produced by inflammasome and involved in gout

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2
Q

IL-2

A

activates macrophages by CD25 receptor

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3
Q

IL-4

A

stimulates healing processes

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4
Q

IL-5

A

eotaxin, (recruits eosinophils)

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5
Q

IL-6

A

Pro-inflammatory cytokine produced by sentinel cells, promotes B cell differentiation

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6
Q

IL-8

A

recruits neutrophils

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7
Q

IL-10

A

stimulates healing processes, anti-inflammatory cytokine

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8
Q

IL-13

A

stimulates healing processes

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9
Q

IL-18

A

inflammatory mediator secreted by inflammasome

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10
Q

TNF

A

Pro-inflammatory cytokine produced by sentinel cells, cytotoxic, upregulate expression of selectins

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11
Q

TGF-beta

A

anti-inflammatory cytokine

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12
Q

IFN-gamma

A

produced by NK cells and Th1 cells to activate macrophages, involved in granulomas

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13
Q

TLR2

A

Recognizes lipoproteins, activates macrophages

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14
Q

TLR4

A

Recognizes LPS, activates macrophages

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15
Q

TLR 7/8

A

stimulated by imiquimod in horses, immune response to equine sarcoids

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16
Q

TLR9

A

Recognizes CpG DNA

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17
Q

CD4

A

receptor on the surface of Th cells, binds MHC-II

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18
Q

CD8

A

receptor on the surface of Tc cells, binds MHC-I

19
Q

CD14

A

involved in binding LPS to TLR4

20
Q

CD18

A

integrin that is affected in leukocyte adhesion deficiency

21
Q

CD25

A

receptors on Treg cells and macrophages for IL-2

22
Q

CD46

A

aka MCP, displaces C2a from C3 convertase

23
Q

CD59

A

protects host cell against MAC formation (blocks C9)

24
Q

CD71

A

receptor for transferrin on macrophages

25
Q

CD79

A

heterodimeric signaling portion of BCR complex

26
Q

I-CAM

A

inter-cellular adhesion molecules (integrins), active during stable adhesion phase of extravasation

27
Q

LBP, MD-2

A

involved in binding LPS to TLR4

28
Q

Fibrinogen and SAA

A

acute phase proteins produced by liver that indicate presence of inflammation, useful to track progress of treatment

29
Q

J chain

A

binds IgM pentamer and secretory IgA dimer

30
Q

FcRn

A

binds IgG within endosomes, recycles antibody back to cytoplasm

31
Q

Fc-epsilon

A

binds IgE with unusually high affinity BEFORE it has bound an antigen

32
Q

Fc-gamma

A

used by NK cells to induce apoptosis of antibody coated tumor cells

33
Q

Th1

A

Th cell activates macrophages

34
Q

Th2

A

Th cell generates inflammatory response

35
Q

Th17

A

Th cell stimulates neutrophil response

36
Q

Tfh

A

Th cell stimulates antibody production from B cells

37
Q

Treg

A

Th cell regulates immune response

38
Q

C3a

A

induces inflammation and recruits phagocytic cells, anaphylatoxin stimulates release of histamine

39
Q

C5a

A

induces inflammation and recruits phagocytic cells, also regulates phagocytosis, acts on neutrophils to increase adherence, anaphylatoxin stimulates release of histamine

40
Q

TCR

A

binds linear peptides displayed by MHC molecules

41
Q

BCR

A

binds specific antigens

42
Q

MHC-I

A

made by all nucleated cells when invaded, presents to Tc cells

43
Q

MHC-II

A

made by APCs, presents to Th cells

44
Q

NLR/RLR

A

NOD-like receptors and rig-like receptors are cytosolic PRRs that detect bacteria and viruses inside cells, trigger inflammasomes

IMMUNO (5 decks)

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