Allergy/Immuno Flashcards
triggers for vasomotor rhinitis
cold air, tearing, pollution and emotion
gold standard of dx food allergy is
oral food test in front of cliniciNS
what kind of allergy testing isnt affected by recent antihistamine use
RAST since is a blood test measuring for IgE
C1 esterase deficiency causes whst
hereditary angioedema
what medicine blunts the effects of epinephrine and should be reversed if the patient is having anaphyaxis and needs epi
beta blocker, give glucagon to reverse
what formula should you use for milk protein allergy
hydrolyzed not SOY
is FPIES IgE mediated
no
when does FPIES get better
as the GI tract matures
Bloody diarrhea or reg diarrhea and emesis in a patient drinking cows formula but not when on clears and eating foods with none whole protein contents , dx?
FPIES
what is food protein induced enterocolitis syndrome
a severe reaction to an allergen about 1-3 hours after ingestion, severe vomiting and diarrhea (cows milk and soy are culprits)
hydrogen breath test tests for what
lactase deficiency
type 3 HS reaction is?
immune complex
ype 4 HS reaction is
cell mediated ( t cell) “poison ivy”
type 2 HS reaction is
antibody mediated “ b cell”
type 1 HS reaxtion is
IGE mediated anaphylaxis
what medication blunts the response to epi? what should you give
beta blokers, give glucagon to reverse the effects
anaphylactoid reactions happen in reponse to whatr
contrast, PCN, vanc, NSAID and opitates
what should be given to prevent an anaphyactoid reaction
diphenhydramine and steroids
nephritis, arthralgias, arthritis and or rash after exposure to medication 1-2 weeks prior is known as
serum sickness
bee sting reactions are due to what
IgE mediated (type 2 HS rxn)
bee sting reactions are due to what
IgE mediated (type 2 HS helper t cells rxn)
bee sting reactions are due to what
IgE mediated (type 2 HS rxn)
helper t cells
CD4
Cytotoxic t cells
CD8
PJP is found in SCID and HyperIgM but not in
Bruton Agammaglobulinemia
chronic or recurrent fungal infections is seen in what kind of condition
t cell/ combined t cell deficiencies
skin testing like ppd check for what kind of HS rexn
Type 4
SCID is what kind of cell deficiency
t AND b cells “ thats why it is called combined”
first 3–6 months with otitis media (OM), thrush, diarrhea, and dermatitis.
SCID
what is the cure for SCID
BMT
what should SCID patient’s not receive
live vaccines
what are two common combined t and b cell deficiences
wiskott aldrich and SCID
lymphopenia is usually in relaiton to what cell line being low
t cells
what imunoglobulin is increased in WIA
IgA, IgM is dereased
what test is used to dx digeorge
FISH
what is an AR condition that involves the ineffective repaire of damaged DNA
ataxia telengeictasia
1st sig of ataxia telengiectasia
cerebellar ataxia around age 1
ataxia telengiectasia has an increased risk of malginancy when
in the 3rd decade of life
ataxia telengiectasia has what kind of recurring illness
pneumonia and sinusitis (AFP is high)
in what condition do B cells fail to form into plasma cells causing a deficiency of all the Ig subtypes
combined variable immunodeficiency
a risk of EBV associated lymphoma is seen in
CVID
recurrent HSV and VZV infections are common in
CVID
IgM will not class switch to IgG due to a missing signal from t and b cells in what syndrome
HyperIgM Syndrome
patients with HyperIgM syndrome have wat kind of infections
PNA, sinusitis and OM
tx for hyperIgM is
IVIG
how to test for b cell deficiency
obtain titers
condition where there are no b cells so no immunoglobulins
x linked agammaglobulinemia
when you see b cell, think of what kind of infection
bacterial
ch50 is a great test to tell between XLA agammaglbulinemia and C1-C4 esterase deficiency how?
CH50 is nl in XLA and low in C1-C4 complement deficiency
this condition:
- presents at 6 month
- only in boys
- recurrent bacterial infections (encapsulated)
- lack of B cells ( aka no Ig’s )
- High T cells
X linked agammaglobulinemia
tx for XLA
IVIG, abx ppx or BMT is curative
transient hypogammaglobulinemia of infance has low what
IgG and IgA, gets better by age 3-6
eosinophils high, eczema and high IgEis
Hyper IgE syndrome
delayed shedding of primary dentition is seen in
Hyper IgE
impaired neutrophil chemotaxisi ( aka no erythema at infection sites) is seen in what condition
Hyper IgE
which complement deficiency is related to herditary angioededma
C1 esterase deficiency
neutropenia, oculocutaneous albinism, low platelets and recurrent indection with staff, what is the confition
chedik higashi syndrome
pancreatic insufficiecny + pancytopneia
schwachman diamond syndrome
pure red cell aplpasia (only red cell line affected) + triphalngeal thumb+macrocytosis
diamond blacfan anemia
