Allergy Flashcards
rash that is dusky, erythematous and slightly edematous with central blistering on hands, trunk, genital regions, perioral area
Fixed drug eruption
defect in maturation of early B cells into mature B cells resulting in absence of plasma cells. Health utnil transplacentaly acquired IgG declines around 6 months of age then develop recurrent serious infections
X linked agammaglobulinemia
Small itchy bumps that form a wheal upon gentle stroking.
Systemic mastocytosis
Recurrent and often severe bacterial and fungal infections and granuloma formation. OFten with aspergillus
Chronic granulomatous disease
Recurrent pyogenic infection, qualitative platelet dysfunction and thrombocytopenia with small platelets, poorly controlled atopic dermatitis. Low IgM, elevated IgA and IgE
Wiskott Aldrich syndrome
recurrent staph abscesses, sinopulmonary infection and intensely pruritic, diffusely distributed eczematous rash
hyperIgE syndrome
What viruses have been implicated as potential contributors in the etiology of DRESS
HHV6, HHV7, CMV and EBV
What is the newborn screening test for SCID
T-cell receptor excision circles (TRECs). Diagnosis then confirmed by flow cytometry
Reddish-brown hyperpigmented lesions with localized erythema and urticarial wheals following stroking or rubbing due to release of histamine from mast cells (darier sign)
Urticaria pigmentosa
IgG mediated reaction typically 6-12 days (but up to 3 weeks) after exposure presenting with fever, skin rashes, joint pain, lymphadenopathy, muscle aches, proteinuria and arthralgia
Serum Sickness
Treatment for serum sickness
stop offending agent, control symptoms with NSAIDs and antihistamines. Resolves on own in 7-10 days
What immunodeficiency is more common in patients with SLE and recurrent pyogenic infections
C2 complement deficiency
Treatment for linear IgA bullous dermatitis
Dapsone
Rings of blisters on the face, trunk and genitalia with IgA on biopsy
Linear IgA bullous dermatitis
