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Dermatology > Allergic Skin Disease Treatment > Flashcards

Allergic Skin Disease Treatment Flashcards

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Dermatology Board Prep flashcards
1
Q

What can be used to treat FAD or food hypersensitivity?

A

Glucocorticoids
Oclacitinib
(ciclosporin)

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2
Q

What class of drug is poor for treating FAD or food hypersensitivity?

A

Antihistamines

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3
Q

How do doses of glucocorticoids differ in cats and dogs?

A

Cat = 2x dog

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4
Q

How can systemic glucocorticoids be administered?

A

IM
SC
Oral

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5
Q

What are the advantages of glucocorticoids?

A

Effective
Cheap
Readily available
Frequently used

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6
Q

What is the target dosage of glucocorticoids?

A

Lowest possible dose given every >2 days

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7
Q

Give 3 examples of topical glucocorticoids…

A

Fuciderm gel
Cortavance - hydrocortisone aceponate spray
Ear drops

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8
Q

When are topical glucocorticoids used?

A

Localised lesions e.g. ears, hotspots

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9
Q

What is a possible adverse effect of topical glucocorticoids?

A

Irreversible skin atrophy

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10
Q

What is the mechanism of action of oclacitinib?

A

JAK-1 receptor inhibitor => reduced production of IL 2.4.6.13.31 => reduced allergy, inflammation and pruritus

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11
Q

What are the possible side effects of oclaitinib?

A 
Diarrhoea
Vomiting
Anorexia
Sub/cutaneous lumps
Lethargy
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12
Q

How can infection of the skin and ears be prevented from reccuring?

A

Skin barrier care - moisturiser, diet
Topical antiseptic/microbial
Control of inflammation

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13
Q

How can acute flare of AD be treated?

A

Identify and remove allergens
Identify and treat secondary microbial infections
Bathe in water/non-irritant shampoo
Glucocorticoids/oclacitinib treatments

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14
Q

What are issues with antihistamines?

A

Efficacy unproven
Different types may need trying
Unlicensed use
More effective in seasonal disease

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15
Q

How is chronic AD treated?

A 
Identify and avoid allergens
Moisturisers
eFA supplementation
Glucocorticoids with pred
Ciclosporin
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16
Q

What is the mechanism of ciclosporin?

A

Calcineurin inhibitor => targeted T-cell depression

17
Q

How long does the benefit of ciclosporin treatment take? What does this mean about its used?

A

4-8wks

Only suitable for chronic itch

18
Q

What are the disadvantages of ciclosporin?

A

Possible adverse effects

Expensive

19
Q

How can flares of AD be prevented?

A

Topical hydrocortisone aceponate spray

ASIT

20
Q

Why is treatment of AS in cats more difficult?

A

Avoidance more difficult
Prevention of self-trauma more difficult
Topical therapy can be problematic
Fewer drugs have been tried

Dermatology (17 decks)

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