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NUTR2101 > Alcohol Metabolism (Case Study) > Flashcards

Alcohol Metabolism (Case Study) Flashcards

1
Q

Iron and Chronic Alcoholism

A

iron is a co-factor for enzymes (p450 2EI detox- enzyme and Fe cofactor)
MEOS is regulated
decrease absorption and loss during stomach ulcers

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2
Q

Stages of Chronic Alcoholism

A
  1. Steatosis
  2. Hepatitis
  3. Cirrhosis
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3
Q

4 mechanisms involved in chronic alcoholism

A
  1. decreased bile production
  2. decreased carrier protein synthesis
  3. decreased conversion to active form
  4. decreased prothrombin production
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4
Q

B1 and Chronic alcoholism

A

Increase excretion
decrease transporters and absorption
Wernicke-Korsakoff Syndrome (nervous system)

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5
Q

Fat-soluble Vits and Chronic alcoholism

A

A, D, E and K - damage in liver = decrease bile means decreased absorption
Vit. D = conversion to active form = decreased major and minor mins (Ca = osteporosis)

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6
Q

Calcium and Chronic alcoholism

A

low Vit. D = low absorption

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7
Q

B2 and Chronic alcoholism

A

Impaors intestine and renal absorption

FAD = alcohol energy metabolism

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8
Q

B3 and Chronic alcoholism

A

increases metabolises alcohol (NAD -MEOS and ADH)

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9
Q

B6 and Chronic alcoholism

A

Blocks PLP formation = weakness

increases excretion

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10
Q

B9 and Chronic alcoholism

A

Storage, blocks folate conjugase (converts to active form

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11
Q

B12 and Chronic alcoholism

A

decreased Storage and absorption

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12
Q

Selenium and Chronic alcoholism

A

Part of antioxidant defense system
Thyroid hormone metabolism as well
- with mental/brain development

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13
Q

Zinc and Chronic alcoholism

A

decreased absorption

converts alcohol to acetaldehyde

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14
Q

Copper and Chronic alcoholism

A

increased requirements for enzyme

it is a cofactor.

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15
Q

Magnesium and Chronic alcoholism

A

increased excretion

decreased absorption

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16
Q

Hormone inhibited by alcohol

A

Anti diuretic hormone = increased urination

17
Q

3 mechanisms involved in chronic alcoholism

A
  1. accumulation of acetaldehyde and of fat
  2. inflammation of the liver
  3. production of free radicals
18
Q

Pathways of Alcohol Metabolism

A
  1. Alcohol dehydrogenase
  2. MEOS
  3. Catalase
Ethanol -> 
ENZYME (ADH, CYP2EI, Catalase) -> 
INTERMEDIATE acetaldehyde -> 
ALDH2 -> 
Acetate (FA = lipogenesis, AA & Ketone Bodies) 
-> energy -> Krebs cycle
19
Q

Alcohol absorption and digestion

A

Alcohol is not digested
20% absorbed in stomach
80% absorbed in liver
- want to get rid of as fast as possible cause it is a toxin.

NUTR2101 (10 decks)

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