Alcohol Flashcards
what advice is given for safe alcohol consumption. (2)
Do not drink > 14 units per week regularly
If you regularly drink 14 units per week, spread evenly over 3 days
why is the concentration of alcohol greater in the liver? (1)
due to the portal vein draining the stomach directly into the liver
what percentage of alcohol is metabolised in the liver?
90% of alcohol is metabolised in the liver
2-5% is excreted in bodily fluids i.e. sweat, urine and breath
what commonly used drug increases alcohol absorption?
Antihistamines
why does alcohol have a quicker effect on women? (2)
lower levels of the enzyme alcohol dehydrogenase in the stomach - more alcohol is absorbed before it begins to be metabolised
Woman have smaller blood volume than men
how much alcohol is removed per hour?
15mg/100ml of blood per hour
what is a fatal dose of alcohol?
> 400mg/100ml
what are the dental problems associated with heavy drinking? (10)
Oral cancers - Risk increases if used alongside smoking
malnourished - this causes oral ulceration, glossitis, angular chellitis, gingivitis.
Neglect for personal care = why oral cancer patients present very late on Trauma Lost dentures Salivary gland enlargement - sialosis Xerostomia Poor wound healing and osteomyelitis which are partly due to the suppression of the immune system. Erosion Bruxism
describe how liver damage increases bleeding? (5)
Reduced production of clotting factors
Reduced Megakaryocyte maturation = few platelets
Reduced Platelet aggregation (reduced number & function)
Reduced absorption of vitamin K (which is used to produce clotting factors) therefore this affects the production of clotting factors 2, 7, 9 and 10
Thrombocytopenia (less platelets) from splenomegaly associated with portal hypertension
describe how liver damage interferes with drug metabolism? (3)
Induces the liver enzymes which increases the metabolism of some drugs which in turn would reduce plasma concentration of the drug and weaken it’s effects.
The liver damage associated with heavy drinking also reduces drug (analgesics, sedatives, antibiotics) and LA metabolism
Alcohol paired with sedative drugs can also suppress the nervous system and prolong the effects of the drug
what problems can arise in patients who drink heavily? (3)
prolonged bleeding
interferes with drug metabolism
GI bleeding - can’t prescribe NSAIDS
describe what occurs when alcohol and warfarin interact?
low amounts of alcohol ( 3 units per day) consumed regularly enhances warfarin metabolism = more powerful
describe what occurs when alcohol and paracetamol interact?
alcohol converts it to an intermediate metabolite which is hepatotoxic (however this is still the analgesic of choice)
describe how disulfiram works in deterring patients from drinking. (4)
Inhibits alcohol dehydroganase which converts acetaldehyde to acetate
If the patient does costume drink this drug inhibits the conversion of acetaldehyde and it accumulates within the body and causes the patient to feel nauseous and start to vomit.
The consumption of large amounts of alcohol with these drugs can lead to arrhythmias and hypotensive collapse
Other drugs can also cause these effects i.e. metronidazole, cephalosporins and ketoconazole.
what is holiday heart syndrome?
those who don’t drink regularly have a period of time where they drink increased amounts = sudden death.