Aggressive Periodontitis

Question 1

Features of Aggressive Periodontitis

Answer 1

Client otherwise healthy
Rapid
Inconsistent with amount of plaque and calculus
Familial aggregation

Question 2

Localized Aggressive Periodontitis

Answer 2

Between puberty and 20years
At least 1 first molar and the rest incisors
No more than 2 other teeth besides first molar and incisors
Robust serum antibody response
Relatively less inflamation

Question 3

Generalized Aggressive Periodontitis

Answer 3

Under age of 30 but some older
At least 3 permanent teeth other than incisors and 1st molar
Poor serum antibody response
Intense inflammation

Question 4

Epidemiology of AP

Answer 4

Primary dentition: prevalence 1-5%

Permant: Below 1% but double for Blacks

Question 5

A. actinomyces and LAP

Answer 5

Associated with it
Facultative anaerobe
Viirulence factors:
Invade across JE and into CT
Leukotoxins that kill innate immune cells
LPS
Collagenases to degrade collagen
Immunosuppressive factors

Question 6

Aggresive Periodontitis and P. Gingivalis

Answer 6

Major one
Anaerobic, gm negative
Proteinases
LPS
Inhibits Il-8 which chemotaxis of neutrophils

Question 7

Inheritance of LAP

Answer 7

most like gene polymorphism

Dominant inheritance

Question 8

Host response of LAP

Answer 8

impaired neutrophil function
More prostaglandin E2 in GCF
Antibody against A.a. is super high
Lots of IgG
Low levels of Ab against P.g in GAP

Question 9

Smokers and GAP

Answer 9

smoking is risk factor
Smoking increases extent and severity
Have poorer response to treatment

Question 10

Treatment

Answer 10

Amoxicilln and Metronidazole
ciprofloxacin and Metronidazole

Maybe surgery
Meticulous therapy