Adult Renal Flashcards

1
Q

How do you assess the patency of a arteriovenous (AV) graft in the forearm ?

A

auscultate the site for a bruit

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2
Q

What are the functions of the kidney ?

A
  • regulate the volume and composition of extracellular fluid
  • excrete waste
  • control BP
  • produce erythropoietin (building block of RBCs, decreased kidney function can lead to anemia)
  • activate vitamin D (important to absorb calcium)
  • regulate acid-base balance
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3
Q

What is Azotemia ?

A

loss of renal function/ increase of metabolic waste products
- aka buildup of waste products

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4
Q

What is Oliguria ?

A

decrease in urinary output
- < 400 mL/day

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5
Q

How suddenly does acute renal failure (injury) occur ?

A

develops over hours/days
- with elevation of BUN & serum Creatinine

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6
Q

What will the lab values in acute renal failure look like ?

A
  • decreased glomerular filtration rate
  • increased serum creatinine
  • increased creatinine clearance (24 hr urine)
  • increased BUN
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7
Q

What is the best indicator of renal failure ?

A

serum creatinine
- represents how much irreversible damage has already occured

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8
Q

What lab value do we use to diagnose chronic kidney disease/ implementation of dialysis ?

A

glomerular filtration rate

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9
Q

What is the best indicator of renal function ?

A

creatinine clearance (24 hr urine)
- represents the degree of seriousness and how well the kidneys are functioning

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10
Q

What does the BUN measure ?

A

the amount of urea nitrogen in the blood
- represents an indirect measurement of renal function and the GFR

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11
Q

What is the best indicator for fluid balance ?

A

daily weights

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12
Q

What does Prerenal causes of acute renal failure mean ?

A

factors that reduce the systemic circulation/perfusion
- heart and blood vessels
- anything that causes decreased perfusion of kidneys and blood flow
- causing reduction in renal blood flow and leading to hypotension/hypovolema
- Ex.) severe blood loss, low BP, sepsis, injury, dehydration,

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13
Q

What does Intrarenal causes of acute renal failure mean ?

A

conditions that cause direct damage to the renal tissue
- kidney
- resulting in impaired nephron function and tubular necrosis
- problem with the kidney itself
- Ex.) med toxicity ischemia, prolonged dehydration/sepsis, nephrotoxic meds (NSAIDS, metformin, vancomycin)

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14
Q

What does Postrenal causes of acute kidney failure mean ?

A

causes involve mechanical obstruction of urinary outflow
- ureters and bladder
- some blockage or injury to downstream flow of kidney
- body detects that the urine isn’t going down so the kidneys will just stop producing that waste
- Ex.) prostatic hypertrophy (enlarged prostate which is very common in older men

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15
Q

What are the 4 phases of Acute Renal Injury (ARI) ?

A
  • initiating (whatever caused the injury)
  • oliguric (kidneys have no perfusion so they stop/decrease urine production until there is enough perfusion)
  • diuretic (tx which is giving fluids or maybe diuretic so kidneys start working again)
  • recovery (can be months and its when the kidneys and labs stabilize)
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16
Q

How long does the oliguric phase last of ARI ?

A

1-7 days

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17
Q

What are some characteristics of the Oliguric phase of ARI ?

A
  • <400 mL/day of urine
  • metabolic acidosis (kidneys can’t excrete acid products of metabolism)
  • hyperkalemia (kidneys can’t excrete potassium) and hyponatremia
  • increased BUN and creatinine
  • hematologic disorders (anemia)
  • fatigue and malaise (sick feeling)
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18
Q

What are some characteristics of the Diuretic phase of ARI ?

A
  • gradual increase in urine output (1-3 L/day to 3-5 L/day)
  • hypovolemia, dehydration
  • hypotension
  • nephrons are still not fully functioning
  • uremia may still be severe, as seen in labs (may look bad for about a few days but should get better gradually)
  • BUN and creatinine begins to normalize
  • persistent S&S
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19
Q

What are some characteristics of the Recovery phase of ARI ?

A
  • begins when GFR increases
  • BUN and creatinine levels plateau (even out) and then decrease
  • renal function can take up to 12 months to stabilize
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20
Q

What causes the hyponatremia in the oliguric phase of ARI ?

A

the damaged tubules can’t conserve sodium
- if left uncontrolled or water excess then it can lead to cerebral edema

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21
Q

Why are hematologic disorders associated with ARI ?

A

impaired erythropoietin production and platelet abnormalities leading to bleeding

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22
Q

Why may a pt have low serum Ca+ in the oliguric phase of ARI ?

A

inability of the kidneys to activate Vitamin D
- may be on Ca+/Vita. D supplement
- when hypocalcemia occurs the parathyroid secretes PTH which stimulates bone demineralization which releases Ca+ from the bones

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23
Q

Why may a pt have elevated serum Phosphate levels in the oliguric phase of ARI ?

A

phosphate is also released when the parathyroid secretes PTH
- pt may be on phosphate binders

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24
Q

How long does the diuretic phase of ARI last ?

A

1-3 weeks

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25
Q

How long does the recovery phase of ARI last ?

A

3-12 months

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26
Q

What are some indications for Renal Replacement Therapy/Dialysis ?

A
  • volume overload
  • elevated serum Potassium level
  • metabolic acidosis
  • BUN level >120 mg/dL (43 mmol/L)
  • significant change in mental status
  • pericarditis, pericardial effusion, or cardiac tamponade
  • clinical status of patient
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27
Q

Why may someone in the recovery phase of AKI need therapy or counseling ?

A

it’s because this phase takes 3-12 months so it can be mentally draining and can cause financial hardships
- also if your kidneys never recover you will need dialysis which is a significant lifestyle change

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28
Q

What is a common cause of AKI ?

A

acute tubular necrosis

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29
Q

What is a common cause of CKD ?

A

diabetic nephropathy

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30
Q

How much urine should you excrete per hour ?

A

80 mL per hr

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31
Q

What is Chronic Kidney Disease (CKD) ?

A

progressive, irreversible loss of kidney function

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32
Q

What is the main diagnostic value when wanting to diagnose CKD ?

A

Glomerular Filtration Rate (GFR)

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33
Q

What are the leading causes of CKD ?

A
  • diabetes (50%)
  • HTN (25%)
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34
Q

Can Vancomycin cause Nephrotoxicity ?

A

yes because if you have impaired kidneys, it can cause delayed and decreased elimination which can lead to accumulation of drugs and the potential for drug toxicity
- doses and frequency have to be adjusted according to severity of kidney disease

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35
Q

Why does pruritus happen in CKD ?

A

the buildup of urea causes the itchiness

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36
Q

When on dialysis, do all patients still produce urine ?

A

after being on dialysis for a while it’s not uncommon for the pt’s to develop anuria/no urine output

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37
Q

What are some S&S of CKD ?

A
  • uremia
  • oliguria (as CKD worsens) & anuria
  • metabolic acidosis (breathe may have uric scent to it because they are trying to breathe it off)
  • anemia
  • infection
  • respiratory system
  • pleural effusion
  • predisposition to respiratory infection
  • dyspnea
  • pulmonary edema
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38
Q

How do we stage chronic kidney disease ?

A

based on decrease in the Glomerular Filtration Rate (GFR)
- normal is 125 mL/min which is reflected by urine creatinine clearance

39
Q

What is the GFR for the last stage of kidney failure ?

A

End-Stage Renal Disease (ESRD) is when GFR <15 mL/min
- needs dialysis

40
Q

How do we diagnose CKD ?

A
  • renal biopsy
  • renal ultrasounds
  • renal scan
  • CT scan
41
Q

What are the most accurate indicators of kidney function ?

A

serum creatinine and 24-hr urine creatinine clearance

42
Q

AS GFR decreases what happens to BUN and serum creatinine ?

A

they will both increase

43
Q

How is carbohydrate metabolism affected by CKD ?

A

have altered carbohydrate metabolism
- pt’s with diabetes who develop uremia may requires less insulin then before onset of CKD
- excretion of insulin is dependent on kidneys

44
Q

How are the triglycerides affected by CKD ?

A

elevated due to alteration of lipid metabolism

45
Q

How are Potassium levels affected by CKD ?

A

hyperkalemia is most prevalent
- will cause fatal dysrhythmias and will want to put on a heart monitor

46
Q

What is the most serious electrolyte disorder in kidney disease ?

A

Hyperkalemia

47
Q

How are Sodium levels affected by CKD ?

A

can be elevated, normal, or low
- because of impaired excretion, Na with water is retained
- dilutional hyponatremia can occur (low sodium due to excess water): S&S are edema, HTN and heart failure

48
Q

How are Calcium levels affected by CKD ?

A

decrease in Vitamin D which causes a decrease of Calcium to be absorbed from the intestine which means there is a decrease of serum Ca+ levels
- Ca must be present for activation of Vita. D to occur

49
Q

How are Phosphate levels affected by CKD ?

A

it builds up in the blood cause of kidney failure
- leads to musculoskeletal disorders

50
Q

How are Magnesium levels affected by CKD ?

A

elevated levels aren’t a problem unless they ingest Mg containing products
- like milk of magnesia, magnesium citrate, antacids with Mg

51
Q

What are some S&S of hypermagnesemia ?

A
  • absence of reflexes
  • decreased mental status
  • cardiac dysrhythmias
  • hypotension
52
Q

What are some neurological manifestations of CKD ?

A

neurologic system starts to deteriorate when the nitrogenous waste products increase
- restless leg syndrome
- muscle twitching
- irritability
- decreased ability to concentrate
- peripheral neuropathy
- altered mental ability
- seizures
- coma

53
Q

What are some GI issues caused by CKD ?

A

every part of GI is affected
- mucosal ulcerations
- stomatitis (mouth ulcerations)
- uremic fetor (urinous odor to breath due to metabolic acidosis)
- GI bleeding
- anorexia, N/V

54
Q

What are some skin issues caused by CKD ?

A
  • pruritus (dry skin, calcium-phosphate deposition in skin, sensory neuropathy) due to urea levels
  • itching can be so intense that it can lead to bleeding or infection secondary to scratching
  • uremic frost (crystalized urea deposits that can be found on the skin of those affected by chronic kidney disease)
55
Q

What are some musculoskeletal manifestations in CKD ?

A

mineral and bone disorders
- decreased activation of Vita. D so impaired calcium absorption in the gut
- causes decreased serum Ca which causes a increase in PTH (parathyroid hormone)
- PTH causes bone demineralization to occur which causes the a increase of Ca and also phosphate

56
Q

What is collaborative care measures for CKD ?

A
  • correction of extracellular fluid volume overload or deficit
  • nutritional therapy
  • erythropoietin therapy
  • calcium supplementation, phosphate binder
  • antihypertensive therapy
  • measures to lower potassium
  • adjustment of drug dosages to degree of renal function
57
Q

What is a pharmacologic therapy method for Hyperkalemia ?

A

IV insulin
- IV glucose to monitor hypoglycemia
- the IV insulin will help draw K+ into the cells when it’s given & the IV glucose is given concurrently to prevent hypoglycemia
- when effects of insulin diminish the K+ shifts back out of cells

58
Q

What is some HTN therapy methods ?

A
  • weight loss
  • lifestyle changes
  • Na and fluid restriction
  • Antihypertension Meds like Diuretics- Lasix
59
Q

What is some information about the medication Lasix ?

A

loop diuretic
- can cause electrolyte imbalances like hypokalemia (can cause dysrhythmias) and dehydration (increases urine output)
- if given IV push fast then it can cause ototoxicity (ringing in ears or hearing loss)
- monitor I&Os, BP, K+ levels

60
Q

What is a side effect of EPO therapy ?

A

development of iron deficiency resulting from increased demand for iron to support erythropoiesis

61
Q

What are some side effects of Iron supplement ?

A
  • gastric irritation, constipation
  • may make stool dark in color
62
Q

What is the goal of Dyslipidemia ?

A
  • lowering LDL (bad cholesterol) below 100 mg/dL
  • triglyceride level below 200 mg/dL
63
Q

What is nutritional therapy for sodium, potassium, phosphate for CKD ?

A
  • Na: restrict from 2-4 g depending on degree of edema, and HTN
  • K: 2-3 g and high Potassium foods should be avoided
  • Phosphate (dairy) : 1000 mg/day
64
Q

What foods are high in Potassium ?

A
  • bananas
  • spinach
  • potatoes and tomatoes
  • oranges
65
Q

Why do CKD pt’s go on a protein restriction ?

A

when protein is ingested then it’s broken down and it creates creatinine
- the unhealthy kidneys lose the ability to remove protein waste and it builds up
- based on stage of kidney disease, nutrition status, and body size

66
Q

What are some conditions that put you at risk for CKD ?

A
  • hx of renal disease
  • HTN
  • DM
  • repeated UTI
67
Q

Which serum laboratory value indicates to the nurse that the client’s CKD is getting worse ?

A

decreased calculated glomerular filtration rate (GFR)

68
Q

What is dialysis ?

A

movement of fluid/molecules across a semipermeable membrane from one compartment to another
- used to correct fluid/electrolyte imbalances and to remove waste products in renal failure
- tx drug overdoses

69
Q

What is diffusion ?

A

movement of solute from an area of greater concentrations to an area of lesser

70
Q

What is osmosis ?

A

movement of fluid from an area lesser to an area of greater concentration of solute

71
Q

Why does a pt get dialysis ?

A

when pt’s uremia can no longer be adequately managed conservatively
- when GFR <15 mL/min

72
Q

What are the 2 types of dialysis ?

A
  • peritoneal dialysis: peritoneal membrane is a filter
  • hemodialysis: goes through the blood and it goes through a external filter and clean blood goes back in
73
Q

Where does the catheter go into in Peritoneal dialysis ?

A

into the peritoneal cavity
- usually done via surgery

74
Q

What is the solution/concentrations of the peritoneal dialysis liquid ?

A
  • 1 to 2 L bags with glucose concentrations of 1.5, 2.5, and 4.25%
  • electrolyte composition similar to plasma
  • solution is warmed to body temp to prevent cramping and pain
75
Q

What are the 3 phases of peritoneal dialysis cycle ?

A

an exchange
- inflow (flow)
- dwell (equilibration)
- drain

76
Q

What happens in the inflow phase of PD ?

A
  • prescribed amount of solution infused through established catheter over about 10 mins
  • after solution infused, inflow clamp closed to prevent air from entering tubing
77
Q

What happens in the dwell phase of PD ?

A
  • diffusion and osmosis occur between pt’s blood and peritoneal cavity
  • duration of time varies, depending on method
78
Q

What happens during the drain phase of PD ?

A
  • 15 to 30 mins
  • may be facilitated gently by massaging abdomen or changing position
  • Goal is to take fluid off (should have more out than put in)
  • like urine, output should be clear and yellow with no cloudiness or dark
79
Q

What is Automated Peritoneal Dialysis ?

A
  • cycler delivers the dialysate
  • times and controls fill, dwell, and drain
  • at night
80
Q

What is continuous ambulatory peritoneal dialysis (CAPD) ?

A

manual exchange
- during the day

81
Q

What are some peritoneal dialysis (PD) complications ?

A
  • exit site infection & peritonitis (can lead to sepsis)
  • hernias
  • lower back problems
  • bleeding
  • pulmonary complications
82
Q

What are the best places to put a fistula or graft ?

A
  • upper arm or forearm
  • leg is the last resort
83
Q

What is a Arteriovenous (AV) fistula ?

A

directly connecting an artery to a vein
- fistula causes extra pressure by increasing the blood flow into the vein, making it grow larger and stronger and providing easy access to the blood vessels.

84
Q

What is a Arteriovenous (AV) graft ?

A

synthetic tube implanted under the skin that connects between the artery and the vein
- providing needly placement access for hemodialysis

85
Q

Why is a AV fistula the “gold standard” ?

A
  • less likely to clot
  • reduces infection risk
  • lasts longer
  • need to palpate for a thrill and listen for a bruit at the site
86
Q

What are some risk factors of AV fistulas ?

A

can cause distal ischemia (no perfusion to peripheral body parts) and aneurysms
- can lead to tissue death, loss of function or loss of limb
- S&S: pain distal to access site, numbness or tingling of fingers, poor capillary refill

87
Q

Why don’t we want to put pressure on AV fistulas or grafts ?

A

can cause it to clot
- no BP, IV lines, or venipunctures on that arm

88
Q

Where is a temporary vascular access port for hemodialysis usually ?

A

internal jugular or femoral vein
- double lumen
- for blood removal and return
- risks: high infection, dislodgement, and malfunction

89
Q

Why do regular RN’s not mess with the dialysis catheters ?

A
  • only for Dialysis RN’s
  • in these catheter’s they put large amounts of heparin after hemodialysis to prevent clotting
  • if you were to flush this catheter then all this Heparin enters their body and it can cause bleeding
  • Dialysis RN’s pull the Heparin out before they use the lumen’s
90
Q

In what direction does dialysate flow in hemodialysis ?

A

in the opposite direction of the blood

91
Q

How is Hemodialysis done ?

A

2 needles placed into fistula or graft
- 1 needle is closer to fistula or red cath lumen pulls blood from pt
- it’s moved through the dialyzer by a blood pump (Heparin is infused as a bolus to prevent clotting)
- dialysate is pumped in and flows in the opposite direction of the blood
- the dialyzed blood is returned to the pt through a 2nd needle or blue cath
- old dialysate is drained and discarded
- needles removed and light pressure

92
Q

Once they come back from hemodialysis, what is the most important vital sign ?

A

Blood pressure
- take lots of fluid from body and want to ensure they didn’t take too much

93
Q

What are some complications from hemodialysis ?

A
  • Hypotension: result from rapid removal of vascular volume (hypovolemia), decreased cardiac output, and decreased systemic intravascular resistance
  • Muscle Cramps: associated with hypotension, hypovolemia, high ultrafiltration rate, and low sodium dialysis solution
  • Blood Loss: blood not being completely rinsed from the dialyzer with saline, accidental separation of blood tubing, dialysis membrane rupture or bleeding after the removal of needles at the end of dialysis