Adult brain tumors

Question 1

Pseudopalisading pleomorphic tumor cells bordering central areas of necrosis, hemorrhage, and/or microvascular proliferation

Answer 1

Glioblastoma multiforme

Question 2

Chicken Wire capillary pattern

Answer 2

Oligodendroglioma

Question 3

Rounded nuclei with a clear cytoplasm often calcified

Answer 3

Oligodendroglioma

“fried egg cells”

Question 4

Frequently appearing near surface of brian in parasagittal region; often asymptomatic

Answer 4

Meningioma (often presents first as seizure or focal neurologic signs from compression)

Question 5

Spindle cells concentrically arranged in a whorled pattern

Answer 5

Meningioma (also contains psammoma bodies)

Question 6

This tumor is associated with VHL when found ____. but is most commonly found____

Answer 6

Hemangioblastoma
associated with VHL when w/ retinal angiomas
Most often found cerebellar

Question 7

Can produce EPO leading to Secondary polycythemia

Answer 7

Hemangioblastoma

Question 8

Closely arranged thin walled capillaries with minimal intervening parenchyma

Answer 8

Hemangioblastoma

Question 9

Bitemporal hemianopia due to pressure on optic chiasm

Answer 9

Pituitary adenoma

Question 10

Most common form of pituitary adenoma and treatment

Answer 10

prolatinoma from lactotrophs

treat with dopamine agonists bromocriptine or cabergoline or transsphenoidal resection

Question 11

S100 +

Answer 11

Schwannoma

Question 12

GFAP +

Answer 12

Glioblastoma multiforme

Question 13

Dense hyppercellualr areas with spindle cells alternating with hyocellular myxoid areas

Answer 13

Schannoma

Question 14

Where is a schwannoma most often seen

Answer 14

Cerebellopiontine angle involving both CNVII and CIII

(but can be along any peripheral nerve