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pharmacology > Adrenergic receptor agonist and antagonist > Flashcards

Adrenergic receptor agonist and antagonist Flashcards

1
Q

α1L may represent a particular conformational state of what receptor

A

α1A

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2
Q

what is the relationship between α2D and α2A?

A

they are species orthologue
hence they are not considered to be a separate subtype

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3
Q

pupilary dilator muscles and pilomotor smooth muscle have which adrenergic receptors on them ?

A

a1
when stimulated the pupilary dilator muscle contracts causing mydriasis while pilomotor contracts causing erect air

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4
Q

most vascular smooth muscles have what receptor present on them?

A

a1

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5
Q

what adrenergic receptor is involved in the inhibition of neurotransmitter release from adrenergic and cholinergic nerve terminals?

A

a2

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6
Q

what receptor on platelets when stimulated causes platelet aggregation

A

a2

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7
Q

what receptor is present on juxtaglomerular cells which when stimulated causes renin release?

A

B1

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8
Q

what adrenergic receptor is present on heart fibres

A

B1

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9
Q

what adrenergic receptors stimulate vascular smooth muscle contraction and what receptor opposes that effect(relaxation)

A

A1 causes contraction (increase peripheral resistance) while B2 causes relaxation of vascular smooth muscle

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10
Q

what receptor present on uterine myometrium when stimulated causes it to relax

A

B2 receptors

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11
Q

stimulation of the B2 receptors on liver causes?

A

glycogenolysis

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12
Q

stimulation of ___ receptor on adipocytes causes lipolysis

A

B3

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13
Q

drugs ending with “-zoline” e.g tetrahydrozoline are

A

A1 receptor agonist

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14
Q

drugs ending with “-olol” e.g nebilolol are

A

B1 antagonist

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15
Q

drugs ending with “-(z)osin” e.g prazosin are what kind of ligands

A

A1 antagonist

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16
Q

drugs ending with “-oxan” e.g imiloxan are what kind of ligands

A

A2 antagonist

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17
Q

drugs ending with “-nidine” e.g clonidine are what kind of ligands

A

A2 agonist

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18
Q

drugs ending with “-terol”(except clenbuterol and xamoterol) e.g albuterol are what kind of ligands

A

B2 agonist

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19
Q

drugs ending with “-egron” e.g amibegron are what kind of ligands

A

B3 agonist

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20
Q

list 3 example of non selective adrenergic agonists

A

Epinephrine (a1, a2, b1, b2)
norepinephrine (a1, a2, b1)
isoprenalol (B1, B2)

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21
Q

mephentermine and metaraminol can act indirectly to cause the release of what neurotransmitter?

A

Noradrenaline
they are both a1 agonists

22
Q

midodrine is an a1 agonist and a pro-drug
T or F

A

T

23
Q

the Prominent Pharmacological Action of a1 agonist is

A

vasoconstriction

24
Q

methoxamine & phenylephrine are used therapeutically as?

A

pressor agents

25
Q

oxymetazoline, tetrahydrozoline, xylometazoline are used therapeutically as

A

nasal decongestants

26
Q

Hypotension, headache, reflex bradycardia, excitability, restlessness, dry mouth are all possible adverse effects of using a1 agonist
T or F

A

F
Hypertension

27
Q

phenylephrine is an example of what ligand

A

a1 agonist

28
Q

guanfacin, guanbenz, clenbuterol, a-methyl-dopa are all examples of ___a__ receptor ___b___
nb: a is receptor name, b is either agonist or antaginist

A

a2 agonist

29
Q

which class of receptors are popularly used as sympatholytics(inhibit the SNS)

A

a2 agonist (methyldopa)
used as a centrally acting sympatholytic vasodilator in hypertensive patients

30
Q

a-methyldopa is converted to ___ in the CNS

A

a-methylnoradrenaline

31
Q

the prominent pharmacological action of a2 agonist is?

A

reduced sympathetic outflow

which results in decreased peripheral vascular resistance and decreased production of aqueous humour

32
Q

a2 agonists can be used therapeutically to treat glaucoma
T or F

A

T

33
Q

Both a1 and a2 agonist can have adverse effects causing bradycardia
T or F

A

T
sedation and dry mouth too

34
Q

possible adverse effect of a2 agonist is hypotension
T or F

A

T
nausea and gastric upset also

35
Q

apraclonidine and brimonidine are applied ___a___ in the treatment of ___b____
a is route/method of administration while b is the pathological instance it is used to treat

A

a topically
b glaucoma and ocular Hypertension
they are both a2 agonist

36
Q

Dobutamine
Denopamine
Xamoterol
are all examples of what receptor ligand

A

B1 agonist

37
Q

what is the preferred route of administration of B1 agonist

A

intravenously

38
Q

the prominent pharmacological action of B1 agonist is

A

increase cardiac output

39
Q

dobutamine is different from other B1 agonist in that it has _____

A

strong ionotropic effect with little chonotropic effect

40
Q

list the long acting B2 agonist

A

formoterol
salmoterol
the long acting b2 agonist have great side effect while the intermediate acting have lesser side effect

41
Q

The prominent pharmacological action of B2 agonist is

A

relaxation of smooth muscle (bronchial and uterine)

42
Q

B2 agonists are used therapeutically to treat?

A

asthma and chronic obstructive pulmonary disease

43
Q

ritodrine is given to treat?

A

premature labour
ritodrine is a B2 agonist

44
Q

Phenoxybenzamine, Phentolamine and Tolazoline; Ergot alkaloids are all examples of what ligands

A

non selective alpha antagonist

45
Q

Indoramin
Urapidil
niguldipine
are all examples of what ligand

A

a1 antagonist

46
Q

a2 antagonist can be used therapeutically to treat urinary retention
T or F

A

F
a1 antagonist

47
Q

Yohimbine is the major active compound found in the bark of

A

Pausinystalia yohimbine

48
Q

a2 antagonist can cause activation of α1 & β1 Rs in the heart & peripheral vasculature
T or F

A

T

49
Q

what receptor ligand can be used in treatment of male sexual function

A

a2 antagonist

50
Q

penbutolol
carteolol
bucindolol
are all examples of what ligand

A

non selective Beta antagonist

pharmacology (8 decks)

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