Adrenergic receptor agonist and antagonist

Question 1

α1L may represent a particular conformational state of what receptor

Answer 1

α1A

Question 2

what is the relationship between α2D and α2A?

Answer 2

they are species orthologue
hence they are not considered to be a separate subtype

Question 3

pupilary dilator muscles and pilomotor smooth muscle have which adrenergic receptors on them ?

Answer 3

a1
when stimulated the pupilary dilator muscle contracts causing mydriasis while pilomotor contracts causing erect air

Question 4

most vascular smooth muscles have what receptor present on them?

Answer 4

a1

Question 5

what adrenergic receptor is involved in the inhibition of neurotransmitter release from adrenergic and cholinergic nerve terminals?

Answer 5

a2

Question 6

what receptor on platelets when stimulated causes platelet aggregation

Answer 6

a2

Question 7

what receptor is present on juxtaglomerular cells which when stimulated causes renin release?

Answer 7

B1

Question 8

what adrenergic receptor is present on heart fibres

Answer 8

B1

Question 9

what adrenergic receptors stimulate vascular smooth muscle contraction and what receptor opposes that effect(relaxation)

Answer 9

A1 causes contraction (increase peripheral resistance) while B2 causes relaxation of vascular smooth muscle

Question 10

what receptor present on uterine myometrium when stimulated causes it to relax

Answer 10

B2 receptors

Question 11

stimulation of the B2 receptors on liver causes?

Answer 11

glycogenolysis

Question 12

stimulation of ___ receptor on adipocytes causes lipolysis

Answer 12

B3

Question 13

drugs ending with “-zoline” e.g tetrahydrozoline are

Answer 13

A1 receptor agonist

Question 14

drugs ending with “-olol” e.g nebilolol are

Answer 14

B1 antagonist

Question 15

drugs ending with “-(z)osin” e.g prazosin are what kind of ligands

Answer 15

A1 antagonist

Question 16

drugs ending with “-oxan” e.g imiloxan are what kind of ligands

Answer 16

A2 antagonist

Question 17

drugs ending with “-nidine” e.g clonidine are what kind of ligands

Answer 17

A2 agonist

Question 18

drugs ending with “-terol”(except clenbuterol and xamoterol) e.g albuterol are what kind of ligands

Answer 18

B2 agonist

Question 19

drugs ending with “-egron” e.g amibegron are what kind of ligands

Answer 19

B3 agonist

Question 20

list 3 example of non selective adrenergic agonists

Answer 20

Epinephrine (a1, a2, b1, b2)
norepinephrine (a1, a2, b1)
isoprenalol (B1, B2)

Question 21

mephentermine and metaraminol can act indirectly to cause the release of what neurotransmitter?

Answer 21

Noradrenaline
they are both a1 agonists

Question 22

midodrine is an a1 agonist and a pro-drug
T or F

Answer 22

T

Question 23

the Prominent Pharmacological Action of a1 agonist is

Answer 23

vasoconstriction

Question 24

methoxamine & phenylephrine are used therapeutically as?

Answer 24

pressor agents

Question 25

oxymetazoline, tetrahydrozoline, xylometazoline are used therapeutically as

Answer 25

nasal decongestants

Question 26

Hypotension, headache, reflex bradycardia, excitability, restlessness, dry mouth are all possible adverse effects of using a1 agonist T or F

Answer 26

F Hypertension

Question 27

phenylephrine is an example of what ligand

Answer 27

a1 agonist

Question 28

guanfacin, guanbenz, clenbuterol, a-methyl-dopa are all examples of ___a__ receptor ___b___ nb: a is receptor name, b is either agonist or antaginist

Answer 28

a2 agonist

Question 29

which class of receptors are popularly used as sympatholytics(inhibit the SNS)

Answer 29

a2 agonist (methyldopa) used as a centrally acting sympatholytic vasodilator in hypertensive patients

Question 30

a-methyldopa is converted to ___ in the CNS

Answer 30

a-methylnoradrenaline

Question 31

the prominent pharmacological action of a2 agonist is?

Answer 31

reduced sympathetic outflow which results in decreased peripheral vascular resistance and decreased production of aqueous humour

Question 32

a2 agonists can be used therapeutically to treat glaucoma T or F

Answer 32

T

Question 33

Both a1 and a2 agonist can have adverse effects causing bradycardia T or F

Answer 33

T sedation and dry mouth too

Question 34

possible adverse effect of a2 agonist is hypotension T or F

Answer 34

T nausea and gastric upset also

Question 35

apraclonidine and brimonidine are applied ___a___ in the treatment of ___b____ a is route/method of administration while b is the pathological instance it is used to treat

Answer 35

a topically b glaucoma and ocular Hypertension they are both a2 agonist

Question 36

Dobutamine Denopamine Xamoterol are all examples of what receptor ligand

Answer 36

B1 agonist

Question 37

what is the preferred route of administration of B1 agonist

Answer 37

intravenously

Question 38

the prominent pharmacological action of B1 agonist is

Answer 38

increase cardiac output

Question 39

dobutamine is different from other B1 agonist in that it has _____

Answer 39

strong ionotropic effect with little chonotropic effect

Question 40

list the long acting B2 agonist

Answer 40

formoterol salmoterol the long acting b2 agonist have great side effect while the intermediate acting have lesser side effect

Question 41

The prominent pharmacological action of B2 agonist is

Answer 41

relaxation of smooth muscle (bronchial and uterine)

Question 42

B2 agonists are used therapeutically to treat?

Answer 42

asthma and chronic obstructive pulmonary disease

Question 43

ritodrine is given to treat?

Answer 43

premature labour ritodrine is a B2 agonist

Question 44

Phenoxybenzamine, Phentolamine and Tolazoline; Ergot alkaloids are all examples of what ligands

Answer 44

non selective alpha antagonist

Question 45

Indoramin Urapidil niguldipine are all examples of what ligand

Answer 45

a1 antagonist

Question 46

a2 antagonist can be used therapeutically to treat urinary retention T or F

Answer 46

F a1 antagonist

Question 47

Yohimbine is the major active compound found in the bark of

Answer 47

Pausinystalia yohimbine

Question 48

a2 antagonist can cause activation of α1 & β1 Rs in the heart & peripheral vasculature T or F

Answer 48

T

Question 49

what receptor ligand can be used in treatment of male sexual function

Answer 49

a2 antagonist

Question 50

penbutolol carteolol bucindolol are all examples of what ligand

Answer 50

non selective Beta antagonist