pharmacodymics - dose response Flashcards
list the 5 factors affecting dose-response relationship
absorption
metabolism
elimination
site of action
presence of other drugs or disease
The relationship between drug conc and observed effect is represented graphically as a
hyperbola
what controls the effect of a drug
the conc of the drug AT THE SITE OF ACTION
not the conc administered but the conc that gets to the site of action
plotting of response against logarithm of dose gives a ____ shape curve
sigmoidal
In dose-response curve
below the threshold there is no adverse effect from exposure to the chemical agent
T or F
T
this means at dose below this the human body can take some insults and still be fine
thresholds for chemicals that cause cancer or chronic responses are easier to determine when compared to death
T or F
F
the potency of a chemical is a measure of it’s strength as a poison
T or F
T
drugs with similar mechanism of action have what kind of curve
their curves are parallel
graded d-r relationship is an all or none relationship
T or F
F
quantal
quantal dr relationship relates dose to frequency of effect in a population
potency is relatively important in the clinical use of drug
T or F
F
it’s unimportant
____ is the ability of drug to produce effect
efficacy
Ld50/Ed50 gives the therapeutic index
T or F
T
therapeutic index is a measure the relative safety of a drug
antagonism caused by action of agonist and antagonist acting at different site is called _____ antagonism
physiological e.g histamine and adrenaline
at same site it is pharmacological (Competitive and non-competitive)
direct interaction(not competition) of agonist and antagonist is chemical e.g dimercapol and mercuric ion
dibenamine is a non competitive inhibitor of
epinephrine
