Adrenal Insufficiency Flashcards
What is the gender distribution of adrenal insufficiency?
F»>M (95% Female)
What is primary adrenal insufficiency? What are some causes?
other causes - Tb, malignancy, adrenal haemorrhage, congenital adrenal hypoplasia
What adrenal antibodies are involved in primary adrenal insufficiency?
What is secondary adrenal insufficiency? What are some causes?
What is tertiary adrenal insufficiency? What are some causes?
What are the RFs for adrenal insufficiency?
What are the symptoms common to all types of adrenal insufficiency?
What are the symptoms specific to primary adrenal insufficiency?
What are the symptoms specific to secondary adrenal insufficiency?
What are the symptoms specific to tertiary adrenal insufficiency?
What are all the symptoms of adrenal insufficiency (in general).
Zona glomerulosa => hyponatreamia => dehydration, salt craving, hypotention, reduced GCS, and lethargy
Zona Fasciculata: ACTH => MSH => hyperpigmentation + Low mood/anxiety => Anorexia/weight loss => GI changes
Zona Reticularis => androgens => loss of libido, infertility/subfertility, hypogonadism, Osteoporosis
Secondary: Raised ICP => headache….
Tertiary: Cushingoid features (incl. Osteoporosis)
What are the common signs of adrenal insufficiency?
List some ddx for adrenal insufficiency.
What is considered a positive finding for adrenal insufficiency in the following investigations:
1. morning cortisol and ACTH
What is considered a positive finding for adrenal insufficiency in the following investigations:
1. synACTHentest
DESCRIBE HOW IT IS DONE
What is considered a positive finding for adrenal insufficiency in the following investigations:
1. serum DHEA
low in primary, normal in others
What is considered a positive finding for adrenal insufficiency in the following investigations:
1. plasma renin
WHat are the adrenal antibodies involved in adrenal insufficiency? What type (1, 2, 3) is it associated with?
What electrolyte imbalances can be see on U+E of adrenal insufficiency
What would you see on CT/MRI adrenals in adrenal insufficiency?
What investigations would you need to confirm adrenal insufficiency and determine the cause? Justify your answers.
Typo: SynACTHen test should be <450 rise for primary and >450 for all else
What is involved in the primary and secondary prevention of adrenal insufficiency?
Describe the acute management of an adrenal crisis.
