Additional INFO Flashcards
What radiopharmaceutical is used for tumor-draining lymph nodes?
a. pentetate
b. pertechnetate
c. sulfur colloid
d. tilmanocept
D. tilmanocept or otherwise known as Lymphoseek
What allows tilmanocept (LYMPHOSEEK) to accumulate in lymphatic tissue and localize in tumor-draining lymph nodes?
the multiple mannose on the molecules within the solution have a high affinity for the receptor proteins found in high concentrations on macrophages and dendritic cells tightly binding to the mannose receptors
What radiopharmaceutical is used to image certain types of neuroendocrine tumors such as neuroblastomas, paragangliomas, and pheochromocytomas?
I 123 MIBG
What radiopharmaceutical is used to image/treat certain types of neuroendocrine tumors such as neuroblastomas, paragangliomas, and pheochromocytomas?
I 131 MIBG meta-iodobenzylguanidine
Florbetaben F18 (Neuraceq) binds to what?
B-amyloid plaques in the brain
What is the indication for the use of F18 Florbetaben (Neuraceq)?
Cognitive impairment of adults being evaluated for Alzheimer’s Disease
What determines the B-amyloid imaging results are negative with F18 Florbetaben (Neuraceq)?
tracer uptake in gray matter is lower than in white matter in all four regions
What does the F18 florbetapir (Amyvid) bind to?
B-amyloid aggregates
What can be seen on images taken with Amyvid F18 (Florbetapir) that indicates positive results?
moderate to frequent amyloid plaques, decreasing the level of contrast of white matter making lines blurry to distinguish because the grey and white matter uptake is similiar
What does F18 flutemetamol (Vizamyl) bind to and what is the indication to use it?
B amyloid aggregates and is used for imaging to estimate B-amyloid neuritic plaque density for patients with cognitive impairment who are being evaluated for Alzheimer’s Disease
How do you know by the images that the results are positive using F18 Flutenetamol (Vizamyl)?
Increase radioactivity in the striatal regions of the brain as well as the absence of white matter
What are the indications to use F18 sodium fluoride?
Staging breast and prostate cancer as well as bone scintigraphy
What is Rb chloride used for in positron emission tomography?
Cardiac perfusion imaging
What are the advantages of using Rb82 chloride for cardiac perfusion imaging compared to SPECT?
superior spatial resolution, better attenuation correction, and lower radiation exposure
What is N13 Ammonia used to image?
It is the preferred PET myocardial perfusion radiopharmaceutical, but it has a very short half-life which requires a cyclotron onsite
How soon after injecting N13 ammonia is imaging started?
4mins
What is the mechanism of biodistribution of Rb82?
It is a potassium analog that is taken up into the myocardium by active transport through the potassium pump like Tl201
When is imaging started for Rb82?
90 to 120 seconds after injection
What is the radiopharmaceutical F-18 Fluciclovine (Axumin) used for in imaging?
For men with prior treatment for prostate cancer and now have prostate specific antigen (PSA) levels that are elevated
What is the radiopharmaceutical Ga68 Dotatate used for?
localization of somatostatin receptor positive neuroendocrine tumors (NETs)
What long after injection of Ga68 Dotatate do you begin imaging the patient?
45-90mins post injection
What is the indication for the use of Y90 ibritumomab tiuxetan (Zevalin)?
to treat non-Hodgkin’s lymphoma (NHL)
What is the indication to use Ra223 Radium dichloride (Xofigo)?
It is used to treat prostate cancer that no longer responds to hormonal or surgical treatments that lower testosterone that spread to the bone but not other parts of the body
What is the indication for the use of I131 Iobenguane (Azedra)?
To treat cancers known as pheochromocytoma and paraganglioma that are positive for the norepinephrine transporter and require systemic anticancer therapy
What is the indication for the use of Lu177 Lutetium dotatate (Lutathera)?
treat gastroenteropancreatic neuroendocrine tumors that are positive for the hormone receptor somatostatin
How is the use of I125 seeds administered to the patient?
It is implanted in the prostate gland of the patient to treat cancer as a braphytherapy
Which is the indication for the use of I125 seeds?
To treat cancer such as prostate, lymph node, lung cancers
