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Steves Exams > Additional INFO > Flashcards

Additional INFO Flashcards

1
Q

What radiopharmaceutical is used for tumor-draining lymph nodes?

a. pentetate
b. pertechnetate
c. sulfur colloid
d. tilmanocept

A

D. tilmanocept or otherwise known as Lymphoseek

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2
Q

What allows tilmanocept (LYMPHOSEEK) to accumulate in lymphatic tissue and localize in tumor-draining lymph nodes?

A

the multiple mannose on the molecules within the solution have a high affinity for the receptor proteins found in high concentrations on macrophages and dendritic cells tightly binding to the mannose receptors

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3
Q

What radiopharmaceutical is used to image certain types of neuroendocrine tumors such as neuroblastomas, paragangliomas, and pheochromocytomas?

A

I 123 MIBG

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4
Q

What radiopharmaceutical is used to image/treat certain types of neuroendocrine tumors such as neuroblastomas, paragangliomas, and pheochromocytomas?

A

I 131 MIBG meta-iodobenzylguanidine

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5
Q

Florbetaben F18 (Neuraceq) binds to what?

A

B-amyloid plaques in the brain

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6
Q

What is the indication for the use of F18 Florbetaben (Neuraceq)?

A

Cognitive impairment of adults being evaluated for Alzheimer’s Disease

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7
Q

What determines the B-amyloid imaging results are negative with F18 Florbetaben (Neuraceq)?

A

tracer uptake in gray matter is lower than in white matter in all four regions

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8
Q

What does the F18 florbetapir (Amyvid) bind to?

A

B-amyloid aggregates

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9
Q

What can be seen on images taken with Amyvid F18 (Florbetapir) that indicates positive results?

A

moderate to frequent amyloid plaques, decreasing the level of contrast of white matter making lines blurry to distinguish because the grey and white matter uptake is similiar

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10
Q

What does F18 flutemetamol (Vizamyl) bind to and what is the indication to use it?

A

B amyloid aggregates and is used for imaging to estimate B-amyloid neuritic plaque density for patients with cognitive impairment who are being evaluated for Alzheimer’s Disease

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11
Q

How do you know by the images that the results are positive using F18 Flutenetamol (Vizamyl)?

A

Increase radioactivity in the striatal regions of the brain as well as the absence of white matter

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12
Q

What are the indications to use F18 sodium fluoride?

A

Staging breast and prostate cancer as well as bone scintigraphy

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13
Q

What is Rb chloride used for in positron emission tomography?

A

Cardiac perfusion imaging

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14
Q

What are the advantages of using Rb82 chloride for cardiac perfusion imaging compared to SPECT?

A

superior spatial resolution, better attenuation correction, and lower radiation exposure

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15
Q

What is N13 Ammonia used to image?

A

It is the preferred PET myocardial perfusion radiopharmaceutical, but it has a very short half-life which requires a cyclotron onsite

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16
Q

How soon after injecting N13 ammonia is imaging started?

A

4mins

17
Q

What is the mechanism of biodistribution of Rb82?

A

It is a potassium analog that is taken up into the myocardium by active transport through the potassium pump like Tl201

18
Q

When is imaging started for Rb82?

A

90 to 120 seconds after injection

19
Q

What is the radiopharmaceutical F-18 Fluciclovine (Axumin) used for in imaging?

A

For men with prior treatment for prostate cancer and now have prostate specific antigen (PSA) levels that are elevated

20
Q

What is the radiopharmaceutical Ga68 Dotatate used for?

A

localization of somatostatin receptor positive neuroendocrine tumors (NETs)

21
Q

What long after injection of Ga68 Dotatate do you begin imaging the patient?

A

45-90mins post injection

22
Q

What is the indication for the use of Y90 ibritumomab tiuxetan (Zevalin)?

A

to treat non-Hodgkin’s lymphoma (NHL)

23
Q

What is the indication to use Ra223 Radium dichloride (Xofigo)?

A

It is used to treat prostate cancer that no longer responds to hormonal or surgical treatments that lower testosterone that spread to the bone but not other parts of the body

24
Q

What is the indication for the use of I131 Iobenguane (Azedra)?

A

To treat cancers known as pheochromocytoma and paraganglioma that are positive for the norepinephrine transporter and require systemic anticancer therapy

25
Q

What is the indication for the use of Lu177 Lutetium dotatate (Lutathera)?

A

treat gastroenteropancreatic neuroendocrine tumors that are positive for the hormone receptor somatostatin

26
Q

How is the use of I125 seeds administered to the patient?

A

It is implanted in the prostate gland of the patient to treat cancer as a braphytherapy

27
Q

Which is the indication for the use of I125 seeds?

A

To treat cancer such as prostate, lymph node, lung cancers

Steves Exams (9 decks)

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