Addison's Disease Flashcards
1
Q
Addison’s Disease
A
reduction of glucocorticoid production
2
Q
causes
A
primary - autoimmune, surgical, infection, trauma, tumour
secondary - pituitary/hypothalamus problem
3
Q
signs
A
hypotension fatigue, weakness GI symptoms syncope hyperpigmentation - common only in primary salt crave
4
Q
investigations
A
ACTH stimulation test/short synthacen test
bloods
21-hydroxylase antibodies
5
Q
investigation results
A
hyperkalaemia hyponatraemia hypoglucose reduced cortisol reduced aldosterone high renin
6
Q
management
A
glucocorticoid replacement - hydrocortisone in the morning
mineralocorticoid replacement - fludrocortisone
7
Q
how would you manage an addisonian crisis
A
double the dose of hydrocortisone
remove fludrocortisone
ABDCDE
8
Q
examples of primary causes
A
autoimmune TB metastases waterhouse fridenchsen syndrome HIV
9
Q
what would the acid base balance be in addisonian crisis
A
hyperkalaemic metabolic acidosis
