Addictions

Question 1

What is Tolerance in Addictions?

Answer 1

Physical Dependence

Question 2

What is Reward Centre in Addictions?

Answer 2

Psychological Craving

Question 3

Definition of Tolerance in Addictions?

Answer 3

reduced responsiveness to drug caused by previous administration

Question 4

What is dispositional tolerance? (5)

Answer 4

• Less Drug Reaches Active/ Site/Absorbed
• Drug Metabolised Faster
• More Excreted
• Increased Rate of Inactive Metabolism
• Decreased Rate of Active Metabolism

Question 5

What is Pharmacodynamic Tolerance? (4)

Answer 5

• Drug has less action at Active Site
• Fewer Drug Receptors
• Down Regulation of Drug Receptors
• Reduced Signalling

Question 6

When a person has drug tolerance what will their response be?

Answer 6

Normal

Question 7

When a person has drug withdrawal what will their response be?

Answer 7

Increased Response

Question 8

Acute Opioid affect?

Answer 8

Constipation

Question 9

Acute Barbiturate effect

Answer 9

Anticonvulsants

Question 10

Acute Coccaine effect?

Answer 10

Elevated Mood

Question 11

Withdrawal effect of Opioid?

Answer 11

Diarrhoea

Question 12

Withdrawal effect of Barbiturate

Answer 12

Convulsion

Question 13

Withdrawl effect of Cocaine?

Answer 13

Depressed Mood

Question 14

In the Reward Centre pathway neurones project from where to where?

Answer 14

ventral tegmental area to nucleus accumbens and prefrontal cortex

Question 15

When VTA neurones are stimulated what is released?

Answer 15

Dopamine = Pleasure

Question 16

What does heroin do to reward pathway?

Answer 16

Increases Firing Rate of Dopaminergic Neurones

Question 17

What does Amphetamine do to reward pathway?

Answer 17

Increases Dopamine Release

Question 18

What does Cocaine do to reward pathway? and what does this cause?

Answer 18

Inhibits Dopamine Uptake which causes craving