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Immune and Lymphatics > adaptive immunity > Flashcards

adaptive immunity Flashcards

1
Q

where are T cell produced

A

bone marrow and mature in thymus

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2
Q

describe the action of dendritic cells

A

present MHC to naive T cells

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3
Q

what type of T cell is produced if dendritic cell presents MHC I

A

CD8
cytotoxic

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4
Q

what type of T cell is produced if dendritic cell presents MHC II

A

CD4
T helper

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5
Q

Th1 is a type of CD4 cell what is its role?

A

activates cell mediated response fro intracellular pathogen

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6
Q

Th2 is a type of CD4 cell what is its role?

A

activates humour response for extracellular pathogen

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7
Q

Th17 is a type of CD4 cell what is its role?

A

inflammatory and fungal response

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8
Q

Treg is a type of CD4 cell what is its role?

A

prevent autoimmunity by regulating the affinity of T cell with antigen

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9
Q

describe the activation of CD4 cell

A

detects antigen using T cell receptor, release of IL2 which binds to its own receptor causing colonel expansion

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10
Q

describe the activation of CD8 cell

A

mature CD4 cells release cytokines, causing CD8 to bind to receptor on infected cell

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11
Q

name the 3 ways in which CD8 cells destroy an infected cell

A

perforin
fas ligand binding
granzyme

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12
Q

describe B cell activation

A

B cell engulfs the pathogen, expressing MHC II to CD4 cell, co stimulatory binding activates B cell causing colonel expansion into plasma and memory cells

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13
Q

what is the first antibody produced by plasma cells

A

IgM (pentameter)

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14
Q

what are cytokines

A

messenger proteins that trigger inflammation

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15
Q

what is the action of IL1 cytokine (2)

A

activates lymphocytes
causes fever

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16
Q

what is the action of IL2 cytokine

A

growth and differentiation of T cells

17
Q

what is the action of IL3 cytokine

A

growth and differentiation of myeloid progenitor cells

18
Q

what is the action of IL4 cytokine

A

differentiation and proliferation of B cells

19
Q

what is the action of IL5 cytokine

A

stimulate eosinophil production

20
Q

what is the action of IL6 cytokine (2)

A

production and differentiation of B cells
fever induction

21
Q

what is the action of IL8 cytokine

A

neutrophil chemotaxis

22
Q

what is the action of IL10 cytokine (2)

A

anti-inflammatory
inhibits Th1

23
Q

what is the action of IL12 cytokine (2)

A

activates natural killer cells
stimulates Th1 production

24
Q

what is the action of TFN alpha cytokine

A

increase vascular permeability

Immune and Lymphatics (12 decks)

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