acute liver disease Flashcards
1
Q
what is it ?
A
rapid development of hepatic dysfunction without prior liver disease
-ie previously normal liver, less than 6 months duration . acute liver failure defined as causing encephalopathy and prolonged coagulation
2
Q
how does oxygen rich blood reach the liver ?
A
via the hepatic artery
3
Q
how does nutrient rich blood reach the liver ?
A
via the portal vein
4
Q
what are the liver functions ?
A
- protein metabolism
- carbohydrate metabolism
- lipid metabolism
- bile acid metabolism
- bilirubin metabolism
- hormone and drug metabolism
- immunological defense
5
Q
what are the true liver function tests ?
A
bilirubin
albumin
prothrombin time
6
Q
clinical features of acute liver disease ?
A
- might not have an features
- jaundice
- lethargy
- nausea
- anorexia
- pain
- itch
- arthralgia
- abnormal LFTs
7
Q
what are the causes of acute liver disease ?
A
- viral hepatitis A,B,C,D,E
- EBV
- toxoplasmosis
- drugs
- shock liver (hypotension/from loss of portal vein blood)
- cholangitis
- alcohol
- malignancy
- chronic liver disease
- ask about paracetamol
RARE:
- budd chiari
- AFLP
- cholestasis of pregnancy