acute liver disease Flashcards

1
Q

what is it ?

A

rapid development of hepatic dysfunction without prior liver disease
-ie previously normal liver, less than 6 months duration . acute liver failure defined as causing encephalopathy and prolonged coagulation

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2
Q

how does oxygen rich blood reach the liver ?

A

via the hepatic artery

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3
Q

how does nutrient rich blood reach the liver ?

A

via the portal vein

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4
Q

what are the liver functions ?

A
  • protein metabolism
  • carbohydrate metabolism
  • lipid metabolism
  • bile acid metabolism
  • bilirubin metabolism
  • hormone and drug metabolism
  • immunological defense
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5
Q

what are the true liver function tests ?

A

bilirubin
albumin
prothrombin time

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6
Q

clinical features of acute liver disease ?

A
  • might not have an features
  • jaundice
  • lethargy
  • nausea
  • anorexia
  • pain
  • itch
  • arthralgia
  • abnormal LFTs
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7
Q

what are the causes of acute liver disease ?

A
  • viral hepatitis A,B,C,D,E
  • EBV
  • toxoplasmosis
  • drugs
  • shock liver (hypotension/from loss of portal vein blood)
  • cholangitis
  • alcohol
  • malignancy
  • chronic liver disease
  • ask about paracetamol

RARE:

  • budd chiari
  • AFLP
  • cholestasis of pregnancy
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