Acute Kidney Injury Flashcards
Acute Kidney Injury manifestations?
increased creatinine and decreased UO
How to approximate minimal normal uring output in an adult?
30cc/hr or 0.5mL/kg/hr
types of AKI
prerenal, intrarenal, postrenal
What is a normal MAP?
70-105
At what MAP will kidney profusion problems occur?
60 or below
Kidney damage occurs how long after hypoperfusion begins?
- > 30 minutes
- < 30, no damage, reversible
Causes of prerenal ACI?
- Hypovolemia (dehydration/bleeding)
- decreased cardiac output (MI or HF)
- decreased peripheral vascular
- decreased renal blood flow
Causes of Intrarenal ACI?
Acute Tubular Necrosis
Hemoglobin
Myoglobin
Interstitial nephritis
Causes of Acute Tubular Necrosis
- Nephrotoxic Injury (drugs)
- Prolonged ischemia
- Sepsis
In which type of acute kidney injury is there direct kidney injury?
intrarenal
Causes of Postrenal acute kidney injury?
mechanical obstruction causes urine to flow back into the kidney (enlarged prostate)
Acute Kidney Injury RIFLE stands for?
Risk Injury Failure Loss End-stage disease
Acute Kidney Injury RIFLE Classification is base on?
creatinine or GFR
Acute Kidney Injury Phases?
- Oliguric
- Diuretic
- Recovery
Acute Kidney Injury Oliguric Phase
- ↓ Urine output to < 400 cc/day (50% of cases)
- geriatric patients at increased risk of increased UO
What is increased in Acute Kidney Injury Oliguric Phase?
Vascular fluid volume, BUN, Creatinine, Potassium, Phosphate
What lab values are decreased in the Oliguric phase of an Acute Kidney Injury?
- pH = metabolic acidosis
- Calcium
- Na may be normal or low
Acute Kidney Injury Diuretic Phase?
- Kidneys recover ability to excrete but not concentrate urine
- Urine output 1-5 Liter/day, 2-3 weeks
Acute Kidney Injury Oliguric Phase begins?
- < 7 days after event
- if last > 10-14 days = worse prognosis
UO during the Oliguric phase of AKI?
- < 400 mL in 50%
Acute Kidney Injury Diuretic Phase labs?
- ↑ BUN and serum creatinine
- ↓ creatinine clearance
- Near end of phase - normalization of lab values
UO during the Diuretic phase of AKI?
1-5 Liter/day, 2-3 weeks
Acute Kidney Injury Recovery Phase Labs?
↓ BUN and serum creatinine
Acute Kidney Injury Recovery Phase lasts?
1-2 wks, up to 12 mo
Acute Kidney Injury Recovery Phase begins?
- when GFR increases
- some permanent loss of renal failure
- enough renal function to maintain healthy life
Prerenal Acute Kidney Injury Diagnostics - Urinalysis
- ↑urine spec. gravity (>1.015)
- Urine osmolality >500mOsm/kg
- ↓urine sodium concentration (<20 mEq/L)
Intrarenal Acute Kidney Injury Diagnostics - Urinalysis
- Urine spec. gravity fixed at 1.010
- Urine osmolality <400mOsm/kg
- ↑sodium in urine (>40mEq/L)
Intrarenal Acute Kidney Injury Diagnostics - Urinalysis
Casts - cells that have taken on the shape of the renal tubules
Acute Kidney Injury Diagnostics ALL?
- Labs
- serum creatinine, BUN
- BUN : Creatinine ratio
- creatinine clearance
- Electrolytes
- Kidney Ultrasound
- CT/MRI
- Kidney biopsy
Primary goals of AKI care?
manage fluids and hypokalemia
1st step of ACI tx?
- Diuretics
- Volume expanders
- Dialysis
How to calculate fluid replacement in ACI?
use past 24hr record and add 600 mL
Hyperkalemia tx for patient with ACI?
- Regular insulin IV (and glucose)
- Sodium bicarb
- Calcium gluconate IV
- Hemodialysis
- Sodium polystyrene sulfonate (Kayexalate)
- Dietary restriction (K restricted to 40 mEq/day)
Why are insulin and glucose given to treat hyperkalemia?
insulin increase k into the cells and glucose to prevent hypoglycemia
What does Sodium polystyrene sulfonate (Kayexalate) do?
- increases k out the bowels an Na in
- diarrhea and/or soft bowels occur
Which medication increases k out and Na retention in the bowels?
Sodium polystyrene sulfonate (Kayexalate)
Dietary restriction for hyperkalemic patient?
40 mEq/day
When do you initiate dialysis in an ACI?
- Volume overload
- Compromised cardiac or pulmonary status
- Hyperkalemia with EKG changes
- Metabolic Acidosis (serum bicarb <15mEq/L)
- BUN >120
- Significant mental status changes
- Pericarditis, pericardial effusion, cardiac tamponade
Acute Kidney Injury Nursing Interventions to maintain homeostasis/monitor renal function?
- Identify and monitor high-risk clients
- Assess fluid balance
- Assess electrolytes and renal parameters
- Evaluate postural hypotension
- Support involved body systems-cardiac, pulmonary
- Balance activity/rest
Acute Kidney Injury Nursing Interventions to Maintain fluid/electrolyte balance?
Monitor:
- Daily weight, I’s & O’s
- Metabolic acidosis
- Uremia
- Hyperkalemia
Management:
- Fluid replacement
- Dialysis
- Continuous Renal
- Replacement Therapy
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Acute Kidney Injury Nursing Interventions to maintain nutrition?
- Calories from carbohydrates and fats
- Dietary restrictions (low Na, k and/or phosphorous)
- Small frequent feedings, limit fluids
Acute Kidney Injury Nursing Interventions to monitor for infection?
Prevent - Avoid indwelling catheter Assess - For UTI - Wounds - Lines - WBC
Acute Kidney Injury Nursing Interventions to prevent skin breakdown
- Positioning
- Prevent pressure areas
- ROM
Manifestations of ACI - Urinary System?
- decreased UO, specific gravity and osmolality
- increased urinary Na
- proteinuria
- casts
Manifestations of ACI CV System?
- volume overoad
- HF
- hypotension (early)
- HTN after FVO
- pericarditis
- pericardial effusion
- dysrhythmias r/t electrolyte imbalances
Manifestations of ACI - Respiratory System?
- pulmonary edema
- pleural effusions
- kussmaul resps
Manifestations of ACI - GI System?
- N/V
- anorexia
- stomatitis
- bleeding
- diarrhea
- constipation
Manifestations of ACI - Hematologic?
- anemia (within 48hrs)
- increased risk of infection
- leukocytosis
- clotting problems
Manifestations of ACI - Neurologic?
- lethargy
- seizures
- asterixis
- memory impairment
What lab values are indicative of an Acute Kidney Injury (AKI)?
decreased:
- Na, pH, bicarb, Ca
increased:
- BUN, creatinine, k, phosphate
What are the causes of AKI in older adults?
dehydration, hypotension, diuretic therapy, aminoglycoside therapy, prostatic hyperplasia, surgery, infection, and contrast media
Increases in serum creatinine occur after what percentage of kidney function loss?
> 50%
What are the most common complications with peritoneal dialysis?
infection at the site, peritonitis, pain, hernias, low back pain, protein loss, bleeding, atelectasis, pneumonia, bronchitis
What are the most common complications with hemodialysis?
hypotension, muscle cramps and blood loss
What type of therapy is used for a hemodynamically unstable patient in place of HD or PD?
Continuous Renal Replacement Therapy (CRRT)