Acute Kidney Injury Flashcards
Acute Kidney Injury manifestations?
increased creatinine and decreased UO
How to approximate minimal normal uring output in an adult?
30cc/hr or 0.5mL/kg/hr
types of AKI
prerenal, intrarenal, postrenal
What is a normal MAP?
70-105
At what MAP will kidney profusion problems occur?
60 or below
Kidney damage occurs how long after hypoperfusion begins?
- > 30 minutes
- < 30, no damage, reversible
Causes of prerenal ACI?
- Hypovolemia (dehydration/bleeding)
- decreased cardiac output (MI or HF)
- decreased peripheral vascular
- decreased renal blood flow
Causes of Intrarenal ACI?
Acute Tubular Necrosis
Hemoglobin
Myoglobin
Interstitial nephritis
Causes of Acute Tubular Necrosis
- Nephrotoxic Injury (drugs)
- Prolonged ischemia
- Sepsis
In which type of acute kidney injury is there direct kidney injury?
intrarenal
Causes of Postrenal acute kidney injury?
mechanical obstruction causes urine to flow back into the kidney (enlarged prostate)
Acute Kidney Injury RIFLE stands for?
Risk Injury Failure Loss End-stage disease
Acute Kidney Injury RIFLE Classification is base on?
creatinine or GFR
Acute Kidney Injury Phases?
Oliguric , Diuretic , Recovery
Acute Kidney Injury Oliguric Phase
- ↓ Urine output to < 400 cc/day (50% of cases)
- geriatric patients at increased risk of increased UO
What is increased in Acute Kidney Injury Oliguric Phase?
Vascular fluid volume, BUN, Creatinine, Potassium, Phosphate
What lab values are decreased in the Oliguric phase of an Acute Kidney Injury?
- pH = metabolic acidosis
- Calcium
- Na may be normal or low
Acute Kidney Injury Diuretic Phase?
- Kidneys recover ability to excrete but not concentrate urine
- Urine output 1-5 Liter/day, 2-3 weeks
Acute Kidney Injury Oliguric Phase begins?
- < 7 days after event
- if last > 10-14 days = worse prognosis
UO during the Oliguric phase of AKI?
- < 400 mL in 50%
Acute Kidney Injury Diuretic Phase labs?
- ↑ BUN and serum creatinine
- ↓ creatinine clearance
- Near end of phase - normalization of lab values
UO during the Diuretic phase of AKI?
1-5 Liter/day, 2-3 weeks