Actions of Medications

Question 1

Drug type is Amiodarone

Answer 1

Anti-arrhythmic

Question 2

Indication of Amiodarone

Answer 2

Cardiac arrest in VF, neg pulse VT
after 3rd shock give 300mg, then after 5th shock give 150mg.

Question 3

4 Actions of Amiodarone

Answer 3

Blocks sodium and potassium channels in cardiac muscle.
Acts to stabilise and reduce electrical irritability of cardiac muscle.
Lengthens cardiac action potential
Prolongs QT interval on ECGs.

Question 4

Drug type Misoprostol

Answer 4

utero-tonic

Question 5

Indication of Misoprostol

Answer 5

Primary or secondary PPH
Miscarriage with excessive bleeding.

Question 6

Actions of Misoprostol

Answer 6

Simulates contraction of the uterus to control bleeding after birth.
7-10mins after oral administration, longer if rectal route.

Question 7

Drug type is TXA 500mg in 5ml.

Answer 7

anti-fibrinolytic

Question 8

Indication for TXA 500mg in 5ml.

Answer 8

Severe haemorrhage

Question 9

Actions of TXA 500mg in 5ml.

Answer 9

Binds with receptor sites on plasmin.
Prevents plasmin from binding and breaking down fibrin, this is preventing the breakdown of blood clots.

Question 10

What drug type is Adrenaline

Answer 10

Sympatho-mimetic

Question 11

Indication of Adrenaline 1 in 10,000

Answer 11

Cardiac arrest
Post ROSC circulatory support.

Question 12

Actions of Adrenaline 1 in 10,000

Answer 12

stimulates both alpha- and beta-adrenergic receptors.
This makes myocardial and cerebral blood flow enhanced during CPR.
CPR becomes more effective due to increased peripheral resistance which improves perfusion pressures.

Question 13

Actions of Furosemide?

Answer 13

acting on the kidneys to increase the output of urine