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Path guide Haem > Acquired Haemolytic Anaemia > Flashcards

Acquired Haemolytic Anaemia Flashcards

1
Q

Compare warm and cold AIHA

A
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2
Q

What is paroxysmal cold haemaglobinuria

A
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3
Q

What is paroxysmal cold haemaglobinuria

A
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4
Q

Pathophysiology of paroxysmal nocturnal haemoglobinuria

A

Acquired loss of protective surface GPI markers on RBCs → complement mediated lysis → chronic intravascular haemolysis, especially at night

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5
Q

Sx and Dx of paroxysmal nocturnal haemoglobinuria

A

Sx - morning haemoglobinuria, thrombosis
Dx - immunophenotyping (altered GPI) or Ham’s test

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6
Q

Mx of paroxysmal nocturnal haemoglobinuria

A

Iron/folate supplements
Prophylactic vaccines/antibiotics
Eculizumab - prevents somplement binding to RBC

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7
Q

MAHA pathophysiology

A

Mechanical RBC destruction (formation of fibrin meshes in vessels) → schistocytes

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8
Q

MAHA causes

A

HUS, TTP, DIC, pre-eclampsia, eclampsia

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9
Q

MAHA Mx

A

Plasma exchange

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10
Q

Summarise TTP

A
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11
Q

Summarise HUS

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Path guide Haem (18 decks)

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