ABX pt 2

Question 1

4 types of antibiotics that use inhibition of protein synthesis

Answer 1

tetracyclines, macrolides, clindamycin, aminoglycosides

Question 2

stand out adverse effects of tetracycline

Answer 2

photosensitivity and yellow/brown discoloring of teeth

Question 3

calcium, iron, mg, al decrease this antibiotics absorption by 50%

Answer 3

tetracycline

Question 4

erythromycin (fire in the belly) most noteworthy adverse effect

Answer 4

QT prolongation –> cardiac death
many drug drug interactions
…not used much

Question 5

most concerning adverse effect of clindamycin

Answer 5

C.diff infection

Question 6

organs most affected by use of gentamicin (aminoglycoside)

Answer 6

ears and kidneys

Question 7

first indication of gentamicin toxicity

Answer 7

headache

Question 8

how do aminoglycosides work?

Answer 8

produce abnormal proteins

Question 9

mneumonic for gentamicin

Answer 9

“that GENT’s gotta BIG GUN!”

Question 10

prototype for sulfonamides

Answer 10

TMP/SMX

Question 11

hi

Answer 11

you’re doing great :)

Question 12

what allergies should you watch out for with TMP/SMX ?

Answer 12

sulfa

Question 13

mechanism of action for sulfonamides

Answer 13

inhibit folate synthesis

Question 14

prototype for tetracyclines

Answer 14

tetracycline

Question 15

prototype for macrolides

Answer 15

erythromycin

Question 16

prototype for aminoglycosides

Answer 16

gentamicin

Question 17

prototype for fluroquinolones

Answer 17

ciprofloxacin

Question 18

mechanism of action for fluroquinolones

Answer 18

disrupt DNA replication

Question 19

most severe side effect for ciprofloxacin

Answer 19

tendon rupture (older and younger)

Question 20

mechanism of action for metronidazole

Answer 20

inhibit nucleic acid synthesis

Question 21

3 main adverse effects to metronidazole

Answer 21

antabuse effects, dark red/brown urine, metallic taste

Question 22

what is drug of choice for C. diff

Answer 22

metronidazole (Flagyl)