Abnormalities, MPD, MDS, Analyzers Flashcards
rare inherited disorder caused by a decrease ability of phagocytes to produce super-oxide and reactive oxygen
chronic granulomatous disease
an autosomal dominant disorder causing a deficiency in myeloperoxidase in the primary granules of neutrophils and monocytes
myeloperoxidase deficiency
autosomal recessive disorder caused by a defect or deficiency in the catabolic enzyme B-glucocerebrosidase
Gaucher Disease
an autosomal recessive lipid storage disease
Niemann-Pick Disease
Reactive leukocytosis above 50X10^3 with a marked left shift
Leukemoid Reactions
Possible space-occupying lesions in the bone marrow
Leukoerythroblastic reactions
clonal hematopoietic disorder caused by genetic mutations
Myeloproliferative Diseases
A dingle genetic translocation in the pluripotent stem cells leading to an overproduction of immature neutrophils
Chronic Myelogenous Leukemia
Jak-2 mutation leading to stem cells proliferating independently of erythropoietin
Polycythemia Vera
similar to polycythemia vera, shows most of the mutation seen in PV just in smaller frequencies
Essential Thrombocythemia
Jak-2 mutation and collagen build-up in bones
Primary myelofibrosis
a group of acquired clonal hematological disorders characterized by progressive pancytopenia and dysfunctional cell lines caused by abnormal stem cells
Myelodysplastic Syndrome
Monocytosis of greater than 1.0x10^3
absence of BCR/ABL gene
less than 20% blasts
dysplasia
chronic myelomonocytic leukemia
based on the detection and measurement of changes in electrical resistance produced by cells as they transverse a small aperature
electronic impedance
measure of resistance to high-voltage electromagnetic current flowing between both electrodes simultaneously
radio frequency
