Abnormal WBCs

Question 1

neutropenia

Answer 1

decrease in neutrophils

Question 2

neutrophilia

Answer 2

increase in neutrophils

Question 3

Morphological Abnormalities in Neutrophils

Answer 3

left shift (band)
hyper-segmentation

Question 4

Toxic Changes in Neutrophils

Answer 4

Pelger-Huet Anomoly (2 dots over e in huet)
Birman Cat Granulation
Chediak-Higashi Syndrome

Question 5

Abnormalities in Eosinophils

Answer 5

degranulation
multiple variable sized vacuoles
eosinophilic degranulation

Question 6

Abnormalities in Lymphocytes

Answer 6

atypical (cleft or indent)
reactive (darker cytoplasm)=antigenically stimulated
auzrophilic granules
Lymphoblasts
plasma cell

Question 7

Abnormalities in Monocytes

Answer 7

lack vacuoles

Question 8

Abnormalities in all cells

Answer 8

smudge cells

basket cells

Question 9

Nuclear Changes

Answer 9

Karyolysis
Pyknosis
Karyorrhexis

Question 10

Degenerative Left Shift

Answer 10

neutropenia
more band cells/immature neutrophils
response to inflammation (acute to severe)

Question 11

Regenerative Left Shift

Answer 11

leukocytes with neutrophilia
more segmented (mature) neutrophils
proper response to inflammation

Question 12

Toxic Changes with Left Shift

Answer 12

Basophilia (bluer and ribosomal RNA)
Foaminess (prominent lysosomes/organelles)
Dohle bodies (blue-grey particles, rough ER)

Question 13

Toxic Neutrophils-species

Answer 13

dogs-bacterial infection

cats-common (if not too many not severely ill)

Question 14

Right Shift

Answer 14

more mature (aging) hyper segmented neutrophils
usually caused by bone marrow disorder (chemotherapy)

Question 15

Pelger-Huet Anomaly

Answer 15

hyposegmentation
granulated nuclei
stay band cells forever
congenital defect in dogs, cats, rabbits, horses

Question 16

Birman Cat Neutrophilic Granulation Anomaly

Answer 16

fine eosinophilic to magenta granules
inherited/recessive trait
healthy cat

Question 17

Chediak-Higashi Syndrome

Answer 17

large fused lysosomes with cytoplasm
stain pink to red
appear healthy but susceptible to infection
Persian cats, cattle, foxes, other (albino)

Question 18

Azurphilic Granules

Answer 18

multiple pink to purple granules

normal do not confuse with inclusions/parasites

Question 19

Lymphoblasts

Answer 19

immature stage

in high numbers Leukemia or extreme antigen

Question 20

smudge cells

Answer 20

aka basket cells or skipocytes

degenerative leukocytes that ruptured

Question 21

karyolysis

Answer 21

dissolution of the nuclear membrane

Question 22

pyknosis

Answer 22

condensing of the nucleus as the cell dies

Question 23

karyorrhexis

Answer 23

fragmentation of the nucleus after cell death

common in inflammatory response

Question 24

parasites: monoctye and lymphocytes

Answer 24

Ehrlichia canis, Ehrlichia chaffeensis

Question 25

parasite: neutrophil and eosinophil

Answer 25

Erlichia ewingii, Anaplasma phagocytophilium

Question 26

viral inclusions

Answer 26

distemper

Question 27

barr body

Answer 27

found in neutrophil

indicates animal is female