Abnormal WBCs Flashcards
neutropenia
decrease in neutrophils
neutrophilia
increase in neutrophils
Morphological Abnormalities in Neutrophils
left shift (band) hyper-segmentation
Toxic Changes in Neutrophils
Pelger-Huet Anomoly (2 dots over e in huet)
Birman Cat Granulation
Chediak-Higashi Syndrome
Abnormalities in Eosinophils
degranulation
multiple variable sized vacuoles
eosinophilic degranulation
Abnormalities in Lymphocytes
atypical (cleft or indent) reactive (darker cytoplasm)=antigenically stimulated auzrophilic granules Lymphoblasts plasma cell
Abnormalities in Monocytes
lack vacuoles
Abnormalities in all cells
smudge cells
basket cells
Nuclear Changes
Karyolysis
Pyknosis
Karyorrhexis
Degenerative Left Shift
neutropenia
more band cells/immature neutrophils
response to inflammation (acute to severe)
Regenerative Left Shift
leukocytes with neutrophilia
more segmented (mature) neutrophils
proper response to inflammation
Toxic Changes with Left Shift
Basophilia (bluer and ribosomal RNA)
Foaminess (prominent lysosomes/organelles)
Dohle bodies (blue-grey particles, rough ER)
Toxic Neutrophils-species
dogs-bacterial infection
cats-common (if not too many not severely ill)
Right Shift
more mature (aging) hyper segmented neutrophils usually caused by bone marrow disorder (chemotherapy)
Pelger-Huet Anomaly
hyposegmentation
granulated nuclei
stay band cells forever
congenital defect in dogs, cats, rabbits, horses
Birman Cat Neutrophilic Granulation Anomaly
fine eosinophilic to magenta granules
inherited/recessive trait
healthy cat
Chediak-Higashi Syndrome
large fused lysosomes with cytoplasm
stain pink to red
appear healthy but susceptible to infection
Persian cats, cattle, foxes, other (albino)
Azurphilic Granules
multiple pink to purple granules
normal do not confuse with inclusions/parasites
Lymphoblasts
immature stage
in high numbers Leukemia or extreme antigen
smudge cells
aka basket cells or skipocytes
degenerative leukocytes that ruptured
karyolysis
dissolution of the nuclear membrane
pyknosis
condensing of the nucleus as the cell dies
karyorrhexis
fragmentation of the nucleus after cell death
common in inflammatory response
parasites: monoctye and lymphocytes
Ehrlichia canis, Ehrlichia chaffeensis
parasite: neutrophil and eosinophil
Erlichia ewingii, Anaplasma phagocytophilium
viral inclusions
distemper
barr body
found in neutrophil
indicates animal is female
