Abnormal Lecture Three Flashcards
Le Magon allowed rats to feed on one flavour and then another. What did he find?
The rats became full of one flavour. But then when given another flavour they ate until they felt full again.
Hertherington and Ranson claimed to have lesioned which area of the brain to produce over eating?
Ventromedial Hypothalmus
Mather et al
Rats learned to eat less of a particular food if it contained intraveteos glucose.
What did Tardoff and Friedman find that ended meal times quicker.
Glucose solution
What did Zeeni (2010) find regarding the response of various cortical regions?
PVN/LHA respond really well to high carbohydrates Vs high proteins.
What did Descastro and Decastro find regarding eating in large groups?
The larger the group the more you ate..
With 7/8 more people you can eat upto 80/90% more.
What did Scalefeni and Nissenbaum find when they paired starch solution and water solution?
Rats preferred starch solution.. Therefore demonstrated taste preferences.
What did Bernstein find regarding natural meal times?
In the natural environment meal times were determined by the size of the previous meal.
In reality they time of meal isn’t affected just the size.
What did Campfield and Smith find regarding high levels of blood glucose?
They injected rats with high levels of blood glucose and found that high blood glucose delayed meal start times.
What did Deutche and ganalez find happened when rats were artificially injected with 50% saline solution in the stomach
It had no overall effect on the total amount that they drank
Matsuda did neuroimaging and found what about the VMH/PVN.
There was a decrease in activity in the VMH/PVN after drinking glucose solution.
What did Schwartz find regarding seratonin.
Seratonin is released during feeding and therefore is broadly inhibitory.
What did Leibowitz find that infusions of Seratonin did?
Reduced carbohydrate intake but didn’t affect the fat intake.
What did Jonstone fine regarding the Hypothalmus?
The lateral Hypothalmus becomes very active during feeding.
What did Anode and Brobreck find happened when the lateral Hypothalmus was damaged.
People simply will not eat and need a hand feeding.
Known as the ‘architechal pleasure centre’
What did Berridge and Valenstein hypothesize.
If the lateral Hypothalmus really is the feeding centre then stimulation should be accompanied by increased palatability for food.
Found that stimulation increased feeding. But had no effect on pleasant or aversive responses.
Conclusion; electrical stimulation of the lateral hypothalamus caused vicarious eating.
What did Cummings find regarding human plasma levels of ghrenlin?
Found that during eating they fell and then rose as the next self initiating meal became imminent.
So if your full ghrenlin plummets and as time goes on it starts to rise again.
What did Wren show regarding ghrenlin?
He demonstrated that the more ghrelin a person has in the stomach the increased appetite.
Also found that neuropeptide Y also increases feeding behaviour (in animals)
What did date et al find that blocking the vagal nerve does?
It blocked ghrelin activation. Blocking the vagal nerve also blocked ghrelin activation of the Hypothalmus.
What did Yee find that led to obesity?
Continuous infusion of chorindine (noanergic alpha-2 receptor agonist)
