Abnormal Immune Response Flashcards
What are the 3 major types of abnormal immune responses?
1) Immunodeficiency
2) Autoimmunity
3) Hypersensitivity
Immuno-?
Immune Response
Deficiency?
Something is missing/absent/incomplete
Immunodeficiency?
The IR occurring partially or is absent. The immune response is compromised.
What are individuals who are immunodeficient at risk for?
It predisposes immunodeficient individuals to disease
Primary?
Something that happens first/ early (eg. primary stage)
Secondary?
Something that happens after primary (eg. secondary phase)
A person has the flu and develops pneumonia. What would pneumonia be considered in this situation?
It would be secondary to the flue because it developed due to the flu
Primary immunodeficiency?
Genetic or congenital (development failure)
Secondary immunodeficiency?
Acquired (post-natal)
What kind of immunodeficiency is occurring in the following example?:
An individual treated with drugs that suppress the IR.
Secondary Immunodeficiency
What kind of immunodeficiency is occurring in the following example?:
Incomplete thymus development
Primary immunodeficiency
What kind of immunodeficiency is occurring in the following example?:
Chemotherapy for cancer
Secondary immunodeficiency
What kind of immunodeficiency is occurring in the following example?:
AIDs- HIV virus
Secondary immunodeficiency because it damages the T helper cells causing it to be a secondary condition to infection
Which cells are considered most important in the IR?
T cells
Humoral immunity?
involves B cells and production of antibodies
Cell-mediated immunity?
Involves T cells
Pyogenic?
Production of pus
What are the types of immunodeficiency?
- B cell disorders
- T cell disorders
- B & T cell disorders
- disorders of phagocytosis
- disorders of complement
- combination of all of these
B cell disorder?
Impaired antibody production [humoral immunodeficiency]
T cell disorder?
Impaired T cell function [& cell-mediated response]
CD4?
Helper cells
CD8?
Cytotoxic cells
What are some of the functions of T cells?
- T cells protect against fungal, protozoan, viral, and intracellular bacterial infections
- T cells control malignant cell proliferation
- T cells are responsible for coordinating the overall IR