ABDO Drugs

Question 1

Main antihistamine anti-emetic drug?

Answer 1

Cyclizine

H1 histamine receptor antagonists

For: Motion sickness, Vestibular disorders

SE: Drowsiness and anti-muscarinic effects

Question 2

Main anti-muscarinic drug?

Answer 2

Hydoscine hydrobromide (in patch and tablets)

Muscarinic receptor antagonists
Blockade of muscarinic receptor-mediated impulses from the labyrinth and from visceral afferents

SE: Constipation, bradycardia and dry mouth

Question 3

name 2 5HT3 antagonists (anti-emetics)?

Answer 3

Dolansetron, ondansetron

Blocks 5HT3 receptors in GIT and CNS

Managing N/V in patients receiving cytotoxics and in postoperative N/V

Question 4

Name 2 neurokinin 1 receptor antagonists?

Answer 4

Aprepitant and fosaprepitant

Adjunct to dexamethasone and a 5HT3 antagonist

N/V associated with chemotherapy

Question 5

Name 2 bulk forming laxatives? MoA?

Answer 5

Ispaghulla husk
Methylcellulose

MoA: Provides increased volume and promotes peristalsis by distension

Question 6

Name 3 stimulate laxatives?

Answer 6

Senna
Dantron
Bisacodyl

Question 7

Name 2 faecal softeners

Answer 7

Arachis oil
Liquid paraffin

MoA: Coat and break up particles

Question 8

main osmotic laxative

Answer 8

Lactulose

Liquid mixes with stool to soften it

Question 9

Name 2 antispasmodics?

Answer 9

Hyoscine butylbromide (buscospan)
Mebeverine

Question 10

Antimobility agent>

Answer 10

Imodium (loperamide)

Question 11

Action of omeprazole?

Answer 11

PPI to reduce gastric

Question 12

Purpose of ranitidine and cinetidine?

Answer 12

Histamine blockading drugs

Question 13

MoA of ranitidine?

Answer 13

• Reduce gastric acid by inhibiting oxyntic cells via the histamine pathway
• Reduces gastric acid production and permits ulcer healing

Question 14

MoA of cinetidine?

Answer 14

H2 blocker

Question 15

2 steps to treat peptic ulcer

Answer 15

Kill H pylori (PPI and antibiotics)

Block histamine (to reduce gastric acid production)