abbreviations

Question 1

The sum of all individual organ
clearances. Usually determined by
plasma sampling

Answer 1

Clearance, Total
(Clt)
Unit: 1/hr/kg

Question 2

The clearance “performed” by the kidney.

Answer 2

Clearance, Renal
(Clr)
UNIT: 1/hr/kg

Question 3

The clearance “performed’ by the liver.

Answer 3

Clearance, Hepatic
(Clh)
UNIIT: 1/hr/kg

Question 4

Highest plasma concentration
achieved following a single non-
intravenous dose of a drug.

Answer 4

Peak plasma concentration
Cmax
UNIT:
mg/ml or mg/liter

Question 5

Plasma concentration , may be
followed by a subscript for time (Cpt– see Cp0 below)

Answer 5

Plasma concentration
Cp0
UNIT:
mg/ml or mg/liter

Question 6

The plasma concentration at zero time. Determine by extrapolating the plasma concentration versus time
“curve” back to the Y (concentration) axis.

Answer 6

Plasma concentration at time zero
Cp0
UNIT:
mg/ml or mg/liter

Question 7

Portion of a non-intravenous dose of drug that reaches the systemic circulation.

Answer 7

Fraction of dose absorbed
(F)
UNIT: None or %

Question 8

Time required to eliminate 50% of
any amount of drug from the body.

Answer 8

Half-life of elimination
T1/2
UNIT: hrs (or) minutes

Question 9

The time that the Cmax (above) is
achieved following a single non-
intravenous dose of drug.

Answer 9

Time of the peak plasma concentration
Tmax
UNIT: hrs (or) minutes

Question 9

The volume calculated using the intercept of the “z” portion of a curve and the Y axisis

Answer 9

Volume of distribution
Vz
UNIT: L/kg