AAMC 2 Flashcards
which Phosphate group from ATP does a kinase take?
the gamma (y) phosphate
does phosphorylation of an amino acid side chain change the charge at all?
yes! phosphorylation makes it negative and hydrophillic
more similar to D and E
break down what I mean when I say “Y229A” variant was made
at the 229th residue, the tyrosine was switched out to an alanine
please explain the venturi effect
the venturi effect is when fluid/air travels through a smaller pipe area, lower pressure because higher velocity. Helps air flow into a breathing tube from the atmosphere
what is it called when two aromatic rings (maybe in G-C in DNA) are stacked on top of each other?
pi stacking is this attraction.
purines are which ones and have how many rings?
purines Adenine Guanine and have two aromatic rings.
when calculating the enthalpy change, (delta H) its as simple as…
looking at the difference in values for H f on the different sides of the equation based on their coefficients (with negative being heat released)
what is the formula for elastic work?
(J) = (0.5)kd^2
please explain what it means to go up 10 dB in scale?
10 dB= 1 B = 10 times more
*change of 30 dB = 10^3 times more since this is a logarithmic scale
concave lenses can only create this type of image
virtual, upright, smaller (also negative bc same side)
protein secondary structure is mostly held together by…
what about tertiary structures? quat?
the H bonds between the N on the backbone and the C=O on the backbone. basically, it is the backbone holding itself together from the N to the C terminal
tertiary structure is based off the R groups (hydrophobic and disulfide bonds)
quaternary structure is mainly held together by H bonds and VDW
what type of VDW force are H bonds?
dipole-dipole permanent
which 3 types of cells are “highly proliferative” (has lots of turnover?)
endothelial cells (inside of vessels), epithelial cells (outside, like skin), and smooth muscle cells (lining of hollow organs)
how does ATP inhibit PFK-1?
this is feedback inhibition in an allosteric location
how do you destroy disulfide bonds between cysteines?
reduction (add an H with acid maybe)