AA amyloidosis

Question 1

Define AA amyloidosis

Answer 1

occurs as a reaction to another illness such as chronic inflammatory dz or infection which causes the liver to produce a protein called serum amyloid A protein (saa) IN HIGH LEVELS

Inflamation –> releases inflammatory cytokines –> hepatic production of SAA protiens –> inadequate breakdown or excess of accumulation –> AA amalyoid accumulation

Question 2

When inflamation goes on what happens with SAA?

Answer 2

Small amount of protein called AA protein will seperate from SAA and deposit in tissues as AA amyloid

Question 3

What is AA

Answer 3

It is a secondary dz, IF YOU find it first you want to figure out what is causing it.

-it is mis folded, something with beta sheets

Question 4

Normal Glomeruli have

Answer 4

evenly dispersed nuclei (purple dots)

Question 5

Abnromal glomeruli

Answer 5

does not have purple dots

Question 6

First Sx of AA AMYLODISIS

Answer 6

PEDEMA

Question 7

Renal biopsy should be done

Answer 7

pedema`, caused by loss of protein in urine which makes fluid leak out of blood vessels and accumulate into tissues

Question 8

Other Sx include

Answer 8

increase protein in urine (foamy pee)

Question 9

Further testing for amyloid

Answer 9

red congo stain, or EM

Question 10

red congo stain

Answer 10

will show an apple green bifrengence if amyloid is present. Preform this after our pt biopsy is positive.

Question 11

Red congo stain, EM and bipopsy will_______. What do you do next to confrim.

Answer 11

-will confirm renal amyloid
you have to apply an extra stain targting particular amyloid proteins
brown = positive

Question 12

What dzs lead to it

Answer 12

-chronic inflamatory conditions: RA, uc, chrons, tb, aids,

Question 13

How to treat AA

Answer 13

manage the primary disease