A9. Unconsciousness due to metabolic origin Flashcards
Unconsciousness due to metabolic origin is usually a disorder of
disorder of awareness
Unconsciousness due to metabolic origin can manifest as
persistent vegetative state (PVS),
also called unresponsive wakefulness syndrome (from lecture).
General symptoms of Unconsciousness due to metabolic origin
- pupils are normal in size and reactive to light
- eye movements are usually full and conjugate
- depressed mental state
- confusion with impairment of consciousness
- depressed respiratory rate
- limb movements are symmetrically reduced and associated with hypotonicity.
- Hemiparesis can occur in:
*non-ketotic hyperosmolar coma, *hepatic encephalopathy.
*hyperglycemic encephalopathy.
*uremic encephalopathy.
Causes of Unconsciousness due to metabolic origin
● Deficiency of essential substrates (glucose, oxygen, vitamin B12)
● Exogenous toxins
(eg. drugs, heavy metals, solvents)
● Endogenous toxins/systemic metabolic diseases
(eg. uremia, hepatic encephalopathy, electrolyte imbalances, thyroid storm
Deficiency of essential substrates that can cause Unconsciousness due to metabolic origin
- glucose
- oxygen
- vitamin B12
Exogenous toxins that can cause Unconsciousness due to metabolic origin
- drugs,
- heavy metals,
- solvents)
example of Endogenous toxins/systemic metabolic diseases which cause Unconsciousness due to metabolic origin
- uremia,
- hepatic encephalopathy,
- electrolyte imbalances,
- thyroid storm
causes of Disorder of glucose metabolism (prolonged hypoglycemia)
Can be due to
* insulin overdose,
* fasting,
* alcohol intoxication and
* rarely insulinomas
how to differentiate between comatose state due to hypoglycemia
and a structural cause.
In hypoglycemia, pupillary light reactions may be intact, while in structural damage they
are usually absent
does hypoglycemia lead to focal necrosis in brain, brainstem or spinal cord?
Hypoglycemia does NOT cause focal necrosis in brain, brainstem or spinal cord.
They remain intact even in long-standing, severe hypoglycemia
In Disorder of glucose metabolism (prolonged hypoglycemia) what is damaged
The superficial layers of the cortex are damaged,
but laminar necrosis (as in global ischemia) is NOT seen
Disorder of glucose metabolism (prolonged hypoglycemia - where does necrosis occur
Necrosis also develops in the
* superficial layers of the cortex
* hippocampus,
* caudate nucleus and
* granular cells of dentate gyrus
what blood glucose level can cause coma?
Blood glucose levels <0,6 mmol/l can cause coma
Hyperosmolar hyperglycemia results from
hyperosmolar effect of severe hyperglycemia
Hyperosmolar hyperglycemia can cause patient to have
involuntary movements,
seizures and
hemiparesis
is vascular thrombosis common in Hyperosmolar hyperglycemia
not uncommon
does ketoacidosis occur in Hyperosmolar hyperglycemia
Ketoacidosis is mild or does not occur
Diabetic ketoacidosis occurs in patient with
known diabetes, but can also be the first manifestation
Diabetic ketoacidosis is often precipitated by
infection
or
poor medical compliance
Diabetic ketoacidosis - what metabolites are accumulated
accumulation of acetone and ketone bodies
patients with Diabetic ketoacidosis present with
- progressive neurological impairment
- with lethargy, and
- ultimately coma
Symptoms of diabetic ketoacidosis
- dehydration (due to osmotic diuresis),
- fatigue,
- weakness,
- headache,
- abdominal pain,
- Kussmal breathing,
- confusion,
- coma
causes of Hypoxia
- May also occur at high altitudes (low O 2 tension of the atmosphere and in drowning
○ Reduced arterial oxygen pressure: e.g. lung disease or PE
■ Hypoxia due to PE causes confusion and lethargy before loss of consciousness
○ Reduced hemoglobin to carry oxygen: anemia or blood loss
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■ pO 2 does not drop, but substrate availability is decreased or O 2 fails to bind to
hemoglobin
○ Reduced flow of blood containing O 2 (ischemic hypoxia): due to reduced cardiac output
→ reduced cerebral blood flow
○ Biochemical block of cerebral utilization of O 2 : e.g. cyanide poisoning (rare), also called
histotoxic hypoxia