A7. Classification of unconscious conditions Flashcards

1
Q

Clear consciousness definition

A

The brain’s ability to react (arousal or
alertness) and the adequate use of contents of memory and to
think (awareness).
Allows the adaptation of the individual to the environment and is the basis of cognition.
Awareness depends on alertness.

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2
Q

The anatomical basis of arousal is the

A

intact functioning of the
ascending reticular activating system (ARAS)

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3
Q

ascending reticular activating system (ARAS)
is
composed of the

A
  1. pontomesencephalic reticular formation,
  2. monoaminergic networks of the diencephalon and
  3. the intralaminar and medial nuclei of the thalamus
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4
Q

Disorders of consciousness:

A
  • Disorder of arousal
  • Disorder of awareness

NOTE: Locked in syndrome - Not disorder of consciousness, but often misdiagnosed as this.

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5
Q

Is locked in syndrome a disorder of consciousness?

A

Not disorder of consciousness, but often misdiagnosed as this.

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6
Q

what are the characteristics of Disorders of arousal

A
  • Reduced arousal
  • sleep-like state
  • won’t react to awakening stimuli.
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7
Q

list Disorder of arousal

A

Somnolence - Mildest form. Awakens with verbal stimuli, but is asleep without stimuli.
Stupor - Patient may open eyes to painful stimuli, verbal is not enough. Slow and inappropriate reaction to stimuli.
Coma - Cannot be awakened. Abnormal posture (decorticate or decerebrate).
i. Coma I - Preserved brainstem reflexes
ii. Coma II - Lost brainstem reflexes

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8
Q

Somnolence

A

Mildest form of Disorder of arousal.
Awakens with verbal stimuli, but is asleep without stimuli.

Disorders of consciousness:
A. Disorder of arousal

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9
Q

Stupor

A
  • Patient may open eyes to painful stimuli, verbal is not enough.
  • Slow and inappropriate reaction to stimuli.

Disorders of consciousness:
A. Disorder of arousal

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10
Q

Coma

A
  • Cannot be awakened.
  • Abnormal posture (decorticate or decerebrate).

i. Coma I - Preserved brainstem reflexes
ii. Coma II - Lost brainstem reflexes

Disorders of consciousness:
A. Disorder of arousal

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11
Q

coma 1 VS coma 2

A

i. Coma I - Preserved brainstem reflexes
ii. Coma II - Lost brainstem reflexes

Disorders of consciousness:
A. Disorder of arousal

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12
Q

characteristics of Disorder of awareness

A
  • Inadequate thinking and behavior.
  • Global CNS function is impaired.
  • Arousal is normal, but content of memory is disturbed, inaccessible or used inappropriately
  • Signs of focal cognitive deficit (e.g. alexia, acalculia) are NOT part of this.
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13
Q

Signs of focal cognitive deficit (e.g. alexia, acalculia) - are they a part of disorder of awareness

A
  • Signs of focal cognitive deficit (e.g. alexia, acalculia) are NOT part of this.
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14
Q

Arousal is normal, but content of memory is disturbed, inaccessible or used inappropriately

A

disorder of awareness

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15
Q

list Disorder of awareness

A
  • Persistent vegetative state (decorticate state, apallic syndrome)
  • Akinetic mutism
  • Confusion
  • Delirium
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16
Q

Persistent vegetative state (decorticate state, apallic syndrome)- how is the brainstem

A

Rostral brainstem remains intact

* Thermoregulation (hypothalamus),
* sleep-wake cycle,
* endocrine system,
* cardiorespiratory and
* other visceral functions are intact.

17
Q

Persistent vegetative state is permenent if

A

Permanent when >30 days

18
Q

in Persistent vegetative state Patients seem to be

A

awake with open eyes and elicitable eye movement reflexes
(e.g. vestibulo-ocular reflex)

19
Q

Persistent vegetative state reaches decortication position after how many days

A

After days/week

20
Q

Persistent vegetative state shows signs of

A

Signs of
* corticospinal tract lesion (e.g. Babinski reflex)
* and primitive reflexes
(suction reflex, Bulldog reflex)
can be elicited

21
Q

a painful stimulus to a patient with Persistent vegetative leads to

A
  • Increased decortication(lesion above RN)
    *Flexion of upper limb,
    *extension of lower limb
  • may see autonomic response (sweating, tachycardia, hyperventilation)
22
Q

causes of Persistent vegetative state

A
  • Extensive functional or structural impairment of cerebral cortex
    (e.g.
    *global cerebral ischemia, *hypoglycemia,
    *renal/hepatic failure,
    *post-convulsive state,
    *Wernicke’s encephalopathy,
    *final stages of cortical dementias)
  • Extensive white matter damage (diffuse axonal injury after head trauma)
  • Bilateral damage to the thalamus
23
Q

list Extensive functional or structural impairment of cerebral cortex which can cause Persistent vegetative state

A
  • global cerebral ischemia
  • hypoglycemia,
  • renal/hepatic failure,
  • post-convulsive state,
  • Wernicke’s encephalopathy,
  • final stages of cortical dementias)
24
Q

Akinetic mutism- how do they appear

A

Awake, but mute and does not move

25
Q

can Akinetic mutism be caused by aphasia?

A

Not caused by aphasia,
can see signs of comprehension

26
Q

how is paralysis excluded in Akinetic mutism

A

Paralysis is excluded by normal withdrawal reactions to painful stimuli.

27
Q

Akinetic mutism what signs are present

A

Usually frontal release signs are present:
sucking reflex,
bulldog reflex,
palmar grasp reflex

28
Q

Akinetic mutism is caused by

A
  • bilateral interruption of connections between the supplementary motor area,
    cingular region
    and midline nuclei of the thalamus
29
Q

list causes of Akinetic mutism

A

○ Jet bleeding (rupture of anterior communicating artery aneurysm)
○ Frontobasal contusion
○ Bilateral ischemia in the anterior cerebral artery territory (Willis-circle variants)
○ Subfalcial herniation
○ Occlusive hydrocephalus
○ Butterfly tumors growing across the corpus callosum into the prefrontal lobes
○ Tumors of third ventricle

30
Q

Confusion def

A

Impaired thinking and attention.
Slow and vague.
Incoherent thinking.
No signs suggestive of delusions.
E.g. after epileptic seizure
(post-convulsive state or tenebrosity)

31
Q

Delirium def

A
  • Disorder of attention and awareness (old definition: also disorder of
    perception. Can use this to differentiate from confusion).
  • Cannot focus, change or fix attention.
  • Disoriented and incoherent thinking.
32
Q

confusion vs delerium

A

delerium is a disorder of attention and awareness
(old definition: also disorder of perception.

Can use this to differentiate from confusion).

33
Q

Delirium- onset?how does it evolve

A

Evolves quickly (hours-24h)

34
Q

Delirium how are symptoms

A

Characteristic diurnal fluctuation of intensity, symptoms deteriorate at night or in an environment lacking stimuli.

35
Q

symptoms of delerium symptoms deteriorate at

A
  • at night or
  • in an environment lacking stimuli.
36
Q

in Delirium how is the sleep wake cycle

A

Typical inversion of sleep/wake cycle

37
Q

Delirium can have autonomic instability such as

A

Autonomic instability (excitatory):
* sweating,
* tachycardia,
* unstable BP

38
Q

Delirium may be a complication of

A
  • right hemispheric lesions,
  • metabolic disorders,
  • drug or
    alcohol