A Revolution in Medicine (1800-1900) Flashcards
How much did population grow by in the 19th Century?
1801 - 16.3 million
1901 - 41.6 million
What were the biggest changes to the UK in the 19th century
- by 1851 more people in towns than countryside
- more people in industry than agriculture
- industry became richer than landownership
- workers badly treated - long hours low wages
What was life in 19th century towns like?
- overcrowded and filthy
- people argued whether it was the government’s responsibility to get involved or not (Chadwick/Bentham)
- technology brought “penny post”, telegraph, newspapers, railways etc - news/people travelled fast
What were the biggest changes to healthcare in 19th century England?
- medicine development e.g. Pasteur and Koch
- Investigations e.g. Snow helped conquer cholera
- Nightingale improved care for sick
- 1899 thousands of volunteers too sick to serve in Boer War
Who were involved in the germ theory?
- Pasteur
- Koch
- Ehrlich
What did Pasteur do?
- established link between germs and disease
- thought micro-organisms were responsible and that a vaccine could be developed from this
- first work on chicken cholera led to effective rabies vaccine in 1880
What led to the first effective rabies vaccine?
Pasteur did work on chicken cholera which led to rabies vaccine in 1880
What did Koch do?
- linked germs to particular diseases
- 1883/4 identified bacteria that caused tb and cholera
- isolated causes of many diseases e.g. diphtheria, typhoid, tetanus, plague etc
- 1905 nobel prize
- invented way to stain bacteria
What did bacteria did Koch identify?
- tuberculosis and cholera bacteria in 1883-4
What did Ehrlich do?
- Koch’s student who epitomised scientific approach to identifying/treating disease
- syphilis treatment 1910
- “magic bullets” drugs designed to target specific germs
How did science and training change in the 19th century?
- 1850 stethoscope widely used
- thermometers
- powerful microscopes
- x-ray machine invented in 1895
- clinical trials held as the importance of observation was realised
- training improved and specialisation within medicine increased e.g. 1850 better knowledge of tropical disease e.g. malaria and yellow fever
When was the x-ray machine invented?
1895 (stethoscope and tropical disease: 1850)
Who had “magic bullets”?
Ehrlich
When was Ehlrich’s syphilis treatment used?
1910
What was the impact of the Germ Theory in Britain?
Koch identified bacteria causing diphtheria in 1891 - serum produced 1894 - Lister used it from 1895 and within 10 years death rate had halved
What was the impact of Koch’s diphtheria serum?
it halved diphtheria death rate in the UK within 10 years
What was the rate of infant mortality in Britain in the 19th century?
1899 - number of babies that died before their first birthday was 142/1000 (neglected, overcrowded, no fresh food)
How did medicine improve in the 19th century? (4)
- machines to make tablets and sugar-coated pills allowed accurate doses and mass production
- aspirin on sale 1899 as everyday painkiller
- Beecham made cold powders in factories in 1859
- Boots chemist began
How did medicine get worse in the 19th century? (5)
- The Book of Household Management 1861 recommended opium powders and laudanum (alcohol/opium) given to children to sent them to sleep/keep them quiet
- no control over medicines
- alcohol major ingredient
- arsenic and mercury in some medicines
- addictive with cocaine and opium
How did surgery mortality rates change in the 19th century?
start of 19th century - 40%
end of 19th century - 10%
Which common ingredients were used in 19th century england?
- Alcohol and opium
- laughing gas (Davy’s Nitrous Oxide)
- Simpson’s chloroform
- Coca leaves
What were the effects of alcohol and opium?
- subdued patients
- could be lethal with wrong dosage
- unreliable
What were the effects of laughing gas?
- Davy invited his friends to inhale the gas and realised it relieved pain in operations (published findings in 1800)
- difficult to control doses
- caused vomiting
- flammable
- patient may wake up
What were the effects of Simpson’s chloroform?
- 1847 used after experiments on himself and friends to reduce childbirth pain
- caused dizziness, sleepiness and unconsciousness
- 1853 Victoria used in childbirth (increasing credibility)
- inhaled
- painkillers seen as unnatural
- stopped being used in 1870s after higher death rates
What were the effects of coca leaves?
- 1850s, eye drops as local anaesthetic in South America
- chemically made in 1891 increased use, operations no longer needed to be painful
- doses had to be carefully controlled
Who were important in antiseptic surgery?
- Lister
2. Semmelweiss
Who was important in aseptic surgery?
- Chamberland and Neuber
- Halsted
- Moyniham
What did Lister do in the development in the development in antiseptic surgery?
- biggest killer in surgery was sepsis infection
- Lister experimented on frogs and a boy with a broken leg
- started to use operating rooms sterilised with carbolic acid - as well as wounds and dressings
- reduced mortality rates in his operations from 46-15% in 3 years
- 1871 invented machine that sprayed carbolic acid everywhere
- published results in 1867 and became known as father of antiseptic surgery
What did Lister do in 1867?
published findings on carbolic acid and how it reduced sepsis infection
What did Lister do in 1971?
invented machine that sprayed carbolic acid everywhere in 1971
How much did Lister’s operation mortality rates drop by?
46 - 15% in 3 years
What was Lister’s opposition?
- surgeons refused to accept that they could be spreading infection
- carbolic acid irritated lungs/skin and had to be prepared