9.3 Intracellular receptors Flashcards
where are steroid hormone receptors located prior to hormone binding
cytoplasmic
primary function of steroid receptors
act as a regulator for gene expression
3 functional domains of a steroid receptor
a hormone binding domain
a DNA-binding domain
a domain that can interact with coactivators to affect the level of gene transcription
why cant a steroid receptor bind to DNA in its inactive state
an inhibitor protein occupies the DNA-binding site
how is the inhibitor protein released from the DNA binding site of a steroid receptor
a signal molecule binds to the hormone binding site which changes the conformation of the receptor
what does a target cells response to a lipid-soluble cell signal depend on
the hormone-receptor complex and the other coactivators present
intracellular receptors can act as
enzymes
