10.7 genetics of cancer

Question 1

mutations in which 2 genes leads to cancer

Answer 1

tumor-suppressor genes and proto-oncogenes

Question 2

which cancerous genes are dominant vs recessive

Answer 2

tumor-suppressor genes are recessive (2 copies must lose function for cancerous phenotype to develop) and proto-oncogenes are dominant (onle 1 copy)

Question 3

what are the 2 types of tumor-suppressor genes

Answer 3

retinoblastoma susceptibility gene (Rb) and p53 gene

Question 4

cell death

Answer 4

apoptosis

Question 5

what do proto-oncogenes become when mutated

Answer 5

oncogenes

Question 6

3 types of proto-oncogenes

Answer 6

1. growth factor receptor
2. Ras protein
3. Src kinase