10.6 control of the cell cycle

Question 1

what are the 2 irreversible steps in the cell cycle

Answer 1

1 DNA replication

2 separation of sister chromatids

Question 2

MPF stands for

Answer 2

maturation-promoting factors

Question 3

MPF was discovered in

Answer 3

frog oocytes

Question 4

MPF is low in which phase

Answer 4

early G2

Question 5

which phase does MPF peak in

Answer 5

mitosis

Question 6

proteins produced in synchrony with the cell cycle

Answer 6

cyclins

Question 7

complexes of a kinase and cyclin

Answer 7

cyclin-dependent kinase (CDK)

Question 8

3 checkpoints that control the cell cycle

Answer 8

1. G1/S
2. G2/M
3. Spindle checkpoint

Question 9

points at which the cell assesses the accuracy of the cell cycle process and can stop if needed

Answer 9

checkpoints

Question 10

checkpoint where the cell makes a commitment to divide

Answer 10

G1/S

Question 11

checkpoint that ensures DNA integrity, passage is a commitment to mitosis

Answer 11

G2/M

Question 12

checkpoint that ensures all chromosomes are attached to spindle fibers with bipolar integrity

Answer 12

spindle checkpoint

Question 13

the cell cycle progresses by the action of

Answer 13

CDK’s

Question 14

activity of CDK is controlled by

Answer 14

phosphorylation

Question 15

APC/C stands for the

Answer 15

anaphase-promoting complex/ cyclosome

Question 16

triggers anaphase and marks the protein securin for destruction

Answer 16

apc/c

Question 17

2 main roles of apc/c in mitosis

Answer 17

1. activate the protease that removes cohesins from sister chromatids
2. destrcution of mitotic cyclins to drive cell out of mitosis