9. Irone and Heme Disorders Flashcards
Adequate/excess iron that is not able to be effectively incorporated into heme
Sideroblastic anemia
Adequate iron stores that have impaired release for incorporation into heme/RBCs
Anemia of chronic disease/inflammation
Iron disorder that is not anemia, with excess iron absorption and stores
Hemochromatosis
RBC morphology seen in IDA
Microcytic/hypochromic
Iron studies (serum iron, ferritin, TIBC, % saturation) of IDA
Serum iron: decreased
Ferritin: decreased
TIBC: increased
% sat: decreased
RBC morphology seen in sideroblastic anemia
Microcytic/hypochromic
RBC morphology seen in lead poisoning
Normocytic/normochromic
Iron studies (serum iron, ferritin, TIBC,% sat) if sideroblastic anemia
Serum iron: increased
Ferritin: increased
TIBC: decreased
% sat: decreased/normal
Anemia resulting from increase in various acute phase reactants present with inflammation which slows iron release
Anemia of chronic disease
Acute phase reactant that decreases iron release from macrophages and hepatocytes
Hepcidin
Acute phase reactant that competes with transferrin for plasma iron
Lactoferrin
Acute phase reactant that binds iron
Ferritin
Iron studies of anemia of chronic inflammation
Serum iron: increased
Ferritin: increased/normal
TIBC: decreased
% sat: decreased
Excess iron will be stored as
Ferritin
Hemosiderin
Organs where excess iron will be stored
Heart
Liver
Pancreas