9. Irone and Heme Disorders Flashcards

1
Q

Adequate/excess iron that is not able to be effectively incorporated into heme

A

Sideroblastic anemia

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2
Q

Adequate iron stores that have impaired release for incorporation into heme/RBCs

A

Anemia of chronic disease/inflammation

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3
Q

Iron disorder that is not anemia, with excess iron absorption and stores

A

Hemochromatosis

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4
Q

RBC morphology seen in IDA

A

Microcytic/hypochromic

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5
Q

Iron studies (serum iron, ferritin, TIBC, % saturation) of IDA

A

Serum iron: decreased
Ferritin: decreased
TIBC: increased
% sat: decreased

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6
Q

RBC morphology seen in sideroblastic anemia

A

Microcytic/hypochromic

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7
Q

RBC morphology seen in lead poisoning

A

Normocytic/normochromic

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8
Q

Iron studies (serum iron, ferritin, TIBC,% sat) if sideroblastic anemia

A

Serum iron: increased
Ferritin: increased
TIBC: decreased
% sat: decreased/normal

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9
Q

Anemia resulting from increase in various acute phase reactants present with inflammation which slows iron release

A

Anemia of chronic disease

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10
Q

Acute phase reactant that decreases iron release from macrophages and hepatocytes

A

Hepcidin

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11
Q

Acute phase reactant that competes with transferrin for plasma iron

A

Lactoferrin

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12
Q

Acute phase reactant that binds iron

A

Ferritin

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13
Q

Iron studies of anemia of chronic inflammation

A

Serum iron: increased
Ferritin: increased/normal
TIBC: decreased
% sat: decreased

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14
Q

Excess iron will be stored as

A

Ferritin

Hemosiderin

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15
Q

Organs where excess iron will be stored

A

Heart
Liver
Pancreas

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16
Q

Gene associated with classic hereditary hemochromatosis

A

HFE gene

17
Q

Gene associated with hepcidin mutation causing hemochromatosis

A

HAMP gene

18
Q

Gene mutation associated with hemojuvelin mutations causing hemochromatosis

A

HJV gene

19
Q

Lack of iron to make adequate heme

A

Iron-deficiency anemia (IDA)