10. Macrocytic Anemias

Question 1

Underlying causes of megaloblastic anemia

Answer 1

Lack of Vitamin B12 and/or folic acid

Question 2

Lack of intrinsic factor leads to

Answer 2

Vitamin B12 inabsorption

Question 3

Parasite that competes for Vitamin B12

Answer 3

Diphyllobothrium latum

Question 4

Deficiency that causes demyelination of neurons

Answer 4

Vitamin B12 deficiency

Question 5

MCV seen in megaloblastic anemia

Answer 5

Elevated; all other tests are decreased

Question 6

Characteristics of neutrophils seen in megaloblastic anemia

Answer 6

Hypersegmented

Question 7

Bone marrow cellularity of megaloblastic anemia

Answer 7

Hypercellular

Question 8

Neutrophil precursors in bone marrow seen in megaloblastic anemia

Answer 8

Giant bands

Metamyelocytes

Question 9

Lab test for megaloblastic anemia; increased in Vit B12 deficiency

Answer 9

Methylmalonic acid (MMA)

Question 10

Lab test for megaloblastic anemia; increased in Vit B12 and folic acid deficiency

Answer 10

Homocysteine

Question 11

A two-part test used to determine if the cause of Vit B12 deficiency is malabsorption, dietary deficiency, or lack of intrinsic factor

Answer 11

Schilling test

Question 12

4 causes of macrocytosis without megaloblastic changes

Answer 12

Normal babies
Liver disease
Alcoholism
Hypothyroidism

Question 13

Anemia resulting from defective DNA synthesis

Answer 13

Megaloblastic anemia