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CPT > 8. Paracetamol > Flashcards

8. Paracetamol Flashcards

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1
Q

What is the mechanism of action of paracetamol?

A

COX-2 selective inhibition in CNS

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2
Q

What is NAPQI?

A

Highly reactive metabolite of paracetamol

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3
Q

What are the symptoms in the first 24hrs of a paracetamol overdose?

A

Nausea
Vomiting
Abdominal pain

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4
Q

What treatment is given in paracetamol overdose?

A

Glutathione thiol replacement - IV acetylcysteine

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CPT (30 decks)

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